Solvent-cast microprotrusion arrays containing active ingredient

A microprotrusion array, comprising:

• an approximately planar base and a plurality of microprotrusions, wherein the microprotrusions comprise at least a first and a second layer arranged roughly parallel to the plane of the planar base, the first and second layers formed of different polymers, the first layer is contained in a distal end of the microprotrusions and comprised of (i) a biodegradable polymer, (ii) one or more components to facilitate biodegradation selected from sugars, sugar alcohols, cyclodextrins and water-swellable polymers, and (iii) an active ingredient, wherein a ratio of weight percent of the biodegradable polymer to weight percent of the one or more components to facilitate biodegradation is in the range of about 6.25:1 to about 1:3.75.