US 10,238,781 B2Granted

Blood bag system and blood treatment method

AssigneeTerumo Kabushiki Kaisha

InventorsMakoto Hirabuki, Masayoshi Higashi

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Abstract

A blood bag system includes: a first bag in which blood containing multiple components is stored; a second bag in which a relative medium-density component is stored; a third bag in which a relative low-density component is stored; a first tube through which the relative low-density component and the relative medium-density component are transported from the first bag to the second bag; and a second tube through which the relative low-density component is transported from the first bag to the third bag. A blood treatment method involves: centrifuging blood containing multiple components in a first bag, transporting a low-density component from the first bag to a third bag through a first tube and transporting a relative medium-density component from the first bag to the second bag through the first tube.

Claims17

Dependent claims

A blood bag system comprising:

a distal-side blood collection tube possessing a distal end and a proximal end, the distal end being connected to a blood collection needle, the proximal end being connected to a distal end of a branch tube;
a first flow blood bag having an upper portion and a lower portion, the upper portion of the first flow blood bag being connected to the distal end of the branch tube, the lower portion of the first flow blood bag being connected to a sampling port;
a proximal-side blood collection tube possessing a proximal end and a distal end, the proximal end being connected to an upper portion of a first bag, the distal end being connected to a sealing member;
the sealing member having a closed configuration and an open configuration, the closed configuration preventing fluid communication between the distal-side blood collection tube and the proximal-side blood collection tube, the open configuration permitting fluid communication between the distal-side blood collection tube and the proximal-side blood collection tube, the sealing member being configured to be converted from the closed configuration to the open configuration by a breaking operation;
the first bag possessing an interior configured to store the whole blood collected from a donor, the whole blood containing a plurality of components including a relative medium-density component and a relative low-density component;
a second bag possessing an interior configured to store the relative medium-density component obtained by centrifugation of the whole blood in the first bag;
a third bag possessing an interior configured to store the relative low-density component obtained by centrifugation of the whole blood in the first bag;
a first tube connecting an upper portion of the first bag and an inlet of the second bag and through which the relative low-density component and the relative medium-density component are transported from the first bag to the second bag;
and
a second tube connecting an outlet of the second bag and an upper portion of the third bag and through which the relative low-density component is transported from the second bag to the third bag.

7 more elements

A blood bag system comprising:

a first bag possessing an interior configured to store the whole blood collected from a donor, the whole blood containing a plurality of components including a relative high-density component, a relative medium-density component, and a relative low-density component;
a second bag possessing an interior configured to store the relative medium-density component obtained by centrifugation of the whole blood in the first bag;
a third bag possessing an interior configured to store the relative low-density component obtained by centrifugation of the whole blood in the first bag;
a first tube connecting an upper portion of the first bag and an inlet of the second bag and through which the relative low-density component and the relative medium-density component are transported from the first bag to the second bag;
a second tube connecting an outlet of the second bag and an upper portion of the third bag and through which the relative low-density component is transported from the second bag to the third bag;
a filter configured to remove predetermined cells;
a third tube connecting the upper portion of the first bag and an inlet of the filter and through which the relative high-density component is transported from the first bag to the filter, the flow of the relative high-density component through the filter being the first flow through the filter;
a fourth bag possessing an interior configured to store the relative high-density component obtained by centrifugation of the whole blood in the first bag;
and
a fourth tube connecting an outlet of the filter and an upper portion of the fourth bag and through which the relative high-density component is transported from the filter to the fourth bag.

7 more elements

A blood bag system comprising:

a distal-side blood collection tube possessing a distal end and a proximal end, the distal end being connected to a blood collection needle, the proximal end being connected to a distal end of a branch tube;
a first flow blood bag having an upper portion and a lower portion, the upper portion of the first flow blood bag being connected to the distal end of the branch tube, the lower portion of the first flow blood bag being connected to a sampling port;
a proximal-side blood collection tube possessing a proximal end and a distal end, the proximal end being connected to an upper portion of a first bag, the distal end being connected to a sealing member;
the sealing member having a closed configuration and an open configuration, the closed configuration preventing fluid communication between the distal-side blood collection tube and the proximal-side blood collection tube, the open configuration permitting fluid communication between the distal-side blood collection tube and the proximal-side blood collection tube, the sealing member being configured to be converted from the closed configuration to the open configuration by a breaking operation;
a first bag possessing an interior configured to store the whole blood collected from a donor, the whole blood containing a plurality of components including a relative medium-density component and a relative low-density component;
a second bag possessing an interior configured to store the relative medium-density component obtained by centrifugation of the whole blood in the first bag;
a third bag possessing an interior configured to store the relative low-density component obtained by centrifugation of the whole blood in the first bag;
a first tube connecting an upper portion of the first bag and an inlet of the second bag and through which the relative low-density component and the relative medium-density component are transported from the first bag to the second bag;
a second tube connecting an outlet of the second bag and an upper portion of the third bag and through which the relative low-density component is transported from the second bag to the third bag;
and
a cross-sectional area of an interior of the second bag at the outlet being smaller than a cross-sectional area of the interior of the second bag at the inlet.

8 more elements

A blood bag system comprising:

a distal-side blood collection tube possessing a distal end and a proximal end, the distal end being connected to a blood collection needle, the proximal end being connected to a distal end of a branch tube;
a first flow blood bag having an upper portion and a lower portion, the upper portion of the first flow blood bag being connected to the distal end of the branch tube, the lower portion of the first flow blood bag being connected to a sampling port;
a proximal-side blood collection tube possessing a proximal end and a distal end, the proximal end being connected to an upper portion of a first bag, the distal end being connected to a sealing member;
the sealing member having a closed configuration and an open configuration, the closed configuration preventing fluid communication between the distal-side blood collection tube and the proximal-side blood collection tube, the open configuration permitting fluid communication between the distal-side blood collection tube and the proximal-side blood collection tube, the sealing member being configured to be converted from the closed configuration to the open configuration by a breaking operation;
a first bag possessing an interior configured to store the whole blood collected from a donor, the whole blood containing a plurality of components including a relative medium-density component and a relative low-density component;
a second bag possessing an interior configured to store the relative medium-density component obtained by centrifugation of the whole blood in the first bag;
a third bag possessing an interior configured to store the relative low-density component obtained by centrifugation of the whole blood in the first bag;
a first tube connecting an upper portion of the first bag and an inlet of the second bag and through which the relative low-density component and the relative medium-density component are transported from the first bag to the second bag;
a second tube connecting an outlet of the second bag and an upper portion of the third bag and through which the relative low-density component is transported from the second bag to the third bag;
and
a cross-sectional area of a lumen of the second tube being smaller than a cross-sectional area of a lumen of the first tube.

8 more elements

Dependencies are inferred from the claim text.

Facts

Application: 15/409,959Filed 19 Jan 2017 · continuation
Priority: JP 2009-25711810 Nov 2009
Published: US 2017/0128643 A111 May 2017
Granted: 26 Mar 2019
Term ends: Not estimatedThe source records don’t support an estimate.

Classification5 codes

A61M 1/029
Blood transfusion apparatus: separating blood components present in distinct layers in a container, not otherwise provided for
A61M 1/0218
Multiple bag systems for separating or storing blood components: with filters
A61M 1/0236
Multiple bag systems for separating or storing blood components: with sampling means, e.g. sample bag or sampling port
A61M 1/3693
Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood…

Family

PCT/JP2010/068808Parent of this continuation · filed 25 Oct 2010
Application13/467,813Parent of this division · filed 9 May 2012
Application14/846,164Parent of this continuation · filed 4 Sep 2015
US 2017/0128643 A1Pre-grant publication · published 11 May 2017
US 9,579,447 B2Parent of this continuation
Application14/846,164Parent of this division
Application13/467,813Parent of this continuation
US 2012/0289926 A1Published application
US 2015/0374899 A1Published application
US 10,238,781 B2This patent

From the US filing history. Foreign family members aren’t listed.