Biodegradable composite scaffold for repairing defects in load-bearing bones
AssigneeThe Curators of the University of Missouri
InventorsDelbert E. Day, Ali Mohammadkhah
Life of this patent
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Abstract
A tissue scaffold for repair and regeneration of bone hard tissue or muscle, skin, or organ soft tissue, including load-bearing bone tissue, the scaffold comprising a core of biocompatible, biodegradable inorganic glass fibers; and a biocompatible, biodegradable, flexible polymer film surrounding the core and adhered to the core.
Claims32
A tissue scaffold for repair and regeneration of bone hard tissue or muscle, skin, or organ soft tissue, including load-bearing bone tissue, the scaffold comprising:
- a core consisting of biocompatible, biodegradable inorganic glass fibers;
- and
- only a biocompatible, biodegradable, flexible polymer film surrounding the core and adhered to the core;
- wherein the core with surrounding polymer film is characterized by a flexural strength of at least about 40 MPa;
- and
- wherein the core is characterized by open and interconnected porosity to facilitate fluid flow into and lengthwise within the scaffold.
A tissue scaffold for repair and regeneration of bone hard tissue or muscle, skin, or organ soft tissue, including load-bearing bone tissue, the scaffold comprising:
- a core consisting of biocompatible, biodegradable inorganic components selected from the group consisting of longitudinally aligned fibers, randomly oriented fibers, and randomly oriented glass particles;
- and
- only a biocompatible, biodegradable, flexible polymer film surrounding the core and adhered to the core;
- wherein the core with the surrounding polymer film is characterized by a flexural strength of at least about 40 MPa;
- and
- wherein the core is characterized by open and interconnected porosity to facilitate fluid flow into and lengthwise within the scaffold.
A tissue scaffold for repair and regeneration of bone hard tissue or muscle, skin, or organ soft tissue, including load-bearing bone tissue, the scaffold consisting of:
- a core consisting of biocompatible, biodegradable inorganic glass fibers or consisting of biocompatible, biodegradable inorganic components selected from the group consisting of longitudinally aligned fibers, randomly oriented fibers, and randomly oriented glass particles;
- and
- a biocompatible, biodegradable, flexible polymer film having a thickness between about 200 and about 600 microns surrounding the core and adhered to the core;
- wherein the core with surrounding polymer film is characterized by a flexural strength of at least about 40 MPa;
- and
- wherein the core is characterized by open and interconnected porosity to facilitate fluid flow into and lengthwise within the scaffold.
Dependencies are inferred from the claim text.