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US 10,238,757 B2Granted
Methods and compositions for detection of cancer
AssigneeCase Western Reserve University
InventorSusann Brady-Kalnay
Life of this patent
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Abstract
A molecular probe for use in detection of cancer cells expressing an Ig superfamily cell adhesion molecule that binds in a homophilic fashion in a subject includes a targeting agent that specifically binds to and/or complexes with a proteolytically cleaved extracellular fragment of the Ig superfamily cell adhesion molecule.
Claims16
A method of detecting cancer cells in a subject comprising:
- administering to a subject a molecular probe that includes a targeting agent that binds to proteolytically cleaved extracellular fragments of receptor protein tyrosine phosphatase (RPTP) cell adhesion molecules expressed in a cancer cell microenvironment in the subject;
- and
- detecting whether cancer cells are present in the subject by detecting binding of the molecular probe to the proteolytically cleaved extracellular fragment of the cell adhesion molecule, wherein binding of the molecular probe to the proteolytically cleaved extracellular fragment is indicative of cancer cells in the subject.
A method of treating cancer in a subject comprising:
- administering to a subject a molecular probe that includes a targeting agent that binds to proteolytically cleaved extracellular fragments of receptor protein tyrosine phosphatase (RPTP) cell adhesion molecules expressed in a cancer cell microenvironment in the subject;
- detecting whether cancer cells are present in the subject by detecting binding of the molecular probe to the proteolytically cleaved extracellular fragment of the cell adhesion molecule, wherein binding of the molecular probe to the proteolytically cleaved extracellular fragment is indicative of the location and/or distribution of the cancer cells in the subject;
- and
- administering a cancer therapeutic to the subject and/or surgically resecting the cancer cells after detection of the cancer cells.
1 more element
Dependencies are inferred from the claim text.