Chikagunya virus RNA vaccines
AssigneeModernaTX, Inc.
InventorsGiuseppe Ciaramella, Sunny Himansu, Eric Yi-Chun Huang, Tal Zaks, Sayda Mahgoub Elbashir
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Abstract
The disclosure relates to tropical diseases such as viral mosquito borne illnesses and the treatment thereof. The invention includes ribonucleic acid vaccines and combination vaccines, as well as methods of using the vaccines and compositions comprising the vaccines for treating and preventing tropical disease.
Claims28
A Chikungunya virus (CHIKV) vaccine comprising at least one ribonucleic acid (RNA) polynucleotide having an open reading frame encoding at least one antigenic CHIKV polyprotein comprising C protein, E1 protein, E2 protein and E3 protein formulated in a lipid nanoparticle that comprises a molar ratio of 20-60% ionizable cationic lipid, 5-25% non-cationic lipid, 25-55% sterol, and 0.5-15% PEG-modified lipid, in an effective amount to induce an immune response in the subject.
Dependencies are inferred from the claim text.