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US 10,238,719 B2Granted
Compositions and kits for enzymatic debridement and methods of using the same
AssigneeRochal Industries, LLP
InventorsJoseph Charles Salamone, Kelly Xiaoyu Chen Leung, Ann Beal Salamone, Katelyn Elizabeth Reilly
Life of this patent
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Abstract
A debridement enzyme for necrotic tissue is described that is not dependent upon proteolytic enzymatic activity but instead utilizes the amylase family of enzymes. The amylases (α-, β-, γ-amylase) are noted for the cleavage of the α-glycosidic bonds of polysaccharides, yielding lower molecular weight carbohydrate/sugar fragments. It has now been found that α-amylase is effective in the debridement of devitalized tissue.
Claims23
A tissue debridement composition comprising:
- 0.1 to 99.5 wt % of an amylase component and optionally a proteolytic enzyme component, wherein a ratio of the amylase component to the proteolytic enzyme component is at least 10:1 by weight;
- and
- at least one pharmaceutically or cosmetically acceptable carrier or excipient in an amount of up to 99.9 wt %, wherein the percentages are based on a total weight of the debridement composition,
- wherein said amylase component comprises at least 80% by weight of α-amylase from Bacillus amyloliquefaciens or Aspergillus oryzae, and wherein the debridement composition is able to debride devitalized or necrotic tissue.
1 more element
A composition for removal of devitalized or necrotic tissue comprising:
- 0.01 to 100 wt % of solid amylase and, optionally, a dry proteolytic enzyme component, wherein a ratio of the amylase component to the proteolytic enzyme component is at least 10:1 by weight;
- and
- optionally a pharmaceutically or cosmetically acceptable carrier or excipient in an amount of up to 99.99 wt %, wherein the percentages are based on a total weight of the solid composition,
- wherein said amylase component comprises at least 80% by weight of α-amylase from a source selected from a group consisting of porcine pancreas, Bacillus amyloliquefaciens, Bacillus subtilis, and Aspergillus oryzae.
1 more element
Dependencies are inferred from the claim text.