Back to results
US 10,238,718 B2Granted
Factor VIII formulation
AssigneeCSL Limited
InventorsUwe Liebing, Hubert Metzner, Christina Bodenbender
Life of this patent
Estimating the term…
Abstract
The invention relates to factor VIII compositions and their use.
Claims24
An aqueous composition, comprising:
- a. a coagulation Factor VIII (FVIII) molecule;
- b. 40 to 195 mM of a sodium salt;
- c. histidine;
- d. at least 1 mM of a calcium salt;
- and
- e. a surfactant,
- wherein [His]+20*[Ca2+]≥180 mM, wherein [Ca2+] is the concentration of calcium ions in the aqueous composition in millimole per liter, and [His] is the concentration of histidine in the aqueous composition in millimole per liter, with the proviso that [His]>0, and wherein the osmolarity of the aqueous composition is 600 mOsmol/L or less.
4 more elements
Dependencies are inferred from the claim text.