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US 10,238,717 B2Granted
Parenteral glucagon formulations
AssigneeLatitude Pharmaceuticals, Inc.
InventorAndrew Chen
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Abstract
This invention relates to compositions of glucagon suitable for administration by manual injection or by an insulin pump or other injection device to treat hypoglycemia. Said compositions comprise glucagon and a sugar, have a final pH between about 1.5 and 3, and are gel-free, chemically-stable at body temperature and pump-able.
Claims21
A parenteral, hypertonic solution composition, comprising:
- a) glucagon at a concentration of 0.01 mg/mL to 3 mg/mL;
- b) a sugar at a concentration of no less than 20% w/v to about 80% w/v, wherein the sugar is a mixture of lactose and dextrose with the concentration of lactose up to about 21.6% w/v, and the sugar to glucagon weight ratio is between 6.67:1 to 8000:1;
- and
- c) water, wherein the pH is between about 1.5 to about 7, wherein the composition is an aqueous composition having an osmotic pressure exceeding 600 mOsmol/L and is substantially free of an organic solvent.
1 more element
Dependencies are inferred from the claim text.