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US 10,238,716 B2Granted
Anti-P2X7 peptides and epitopes
AssigneeBiosceptre (Aust) Pty Ltd
InventorsJulian Alexander Barden, Angus Gidley-Baird
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Abstract
The invention relates to the identification of a novel epitope on non-function P2X7 receptors which are implicated in cancer. The epitope includes a region from two adjacent monomers within the three subunit receptor. Antibodies which bind to the epitope and peptides for generating the antibodies are described. The antibodies and peptides are useful in the diagnosis and treatment of cancer.
Claims3
A method of treating cancer in an individual, the method comprising administering a peptide defined by the formula:
- (A)(Xn)(B), wherein:
- (A) is the sequence of amino acids of GHNYTTRNILP (SEQ ID NO:
- 8);
- (Xn) is a linker of from 10 to 30 angstroms in length, said linker consisting of one or more amino acid residues;
- (B) is the sequence of amino acids of AKYYKENNVEK (SEQ ID NO:
- 9),
- wherein administering the peptide elicits an immune response in the individual and formation of an antibody for binding a non-functional P2X7 receptor in the individual,
- thereby treating cancer in the individual.
5 more elements
Dependencies are inferred from the claim text.