Methods for treating or reducing the risk of arthritis in a subject by administering gelsolin
AssigneeThe Brigham and Women's Hospital, Inc.
InventorsThomas P. Stossel, Anna Charlotta Teresia Magnuson Osborn, Andrej Tarkowski
Life of this patent
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Abstract
The invention relates to the use of gelsolin to treat inflammatory diseases (e.g., rheumatoid arthritis) and to the use of gelsolin to diagnose, monitor, and evaluate therapies of inflammatory diseases (e.g., rheumatoid arthritis).
Claims17
A method for treating a subject having arthritis, or for reducing the risk of developing arthritis in a subject, comprising:
- administering an effective amount of gelsolin to a subject in need of such a treatment to treat the subject.
A method for treating a subject having arthritis, or for reducing the risk of developing arthritis in a subject, comprising:
- administering an effective amount of gelsolin to a subject in need of such a treatment to raise the level of gelsolin in the subject above a predetermined value, thereby treating or reducing the risk of arthritis in a subject.
A method for reducing the risk of developing arthritis in a subject, comprising:
- (i) selecting a subject on the basis that the subject is known to have a below-normal level of gelsolin;
- and
- (ii) administering gelsolin or gelsolin and a second agent to the subject in an effective amount to reduce the risk of the subject developing arthritis.
A method for treating a subject with a below-normal level of gelsolin comprising:
- (i) treating the subject with a first therapy for treating or reducing the risk of arthritis,
- (ii) obtaining a level of gelsolin in the subject,
- (iii) comparing the level of gelsolin obtained in (ii) to a predetermined value corresponding to a predetermined level of gelsolin, and if the predetermined level of gelsolin is not reached,
- (iv) treating the subject with a second agent for treating or reducing the risk of arthritis, and repeating (ii) and (iii) until the predetermined level of gelsolin is reached.
Dependencies are inferred from the claim text.