Method for forming an immune-tolerant site and method for attracting immunosuppressive cells
AssigneesKyoto University, ARKRAY, Inc., Kyoto Prefectural Public University Corporation
InventorsHiroo Iwata, Rei Kuwabara, Masahide Hamaguchi, Kunio Hirano, Shimon Sakaguchi
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Abstract
A method for forming an immune-tolerant site, and a method for attracting immunosuppressive cells, comprising contacting an agent comprising SEK-1005 (Ser, 3-hydroxy-N-[2-hydroxy-1-oxo-2-tetrahydro-2-hydroxy-6-methyl-5-(2-methylpropyl)-2H-pyran-2-yl-propyl]-Leu-Pip(hexahydro-3-pyridazinecarbonyl)-N-hydroxy-Ala-N-methyl-Phe-Pip-rho-lactone) and/or fibroblast growth factor (FGF) with a site in the body tissue.
Claims8
A method for forming an immune-tolerant site in a body tissue comprising contacting an agent comprising SEK-1005 (Ser,3-hydroxy-N-[2-hydroxy-1-oxo-2-tetrahydro-2-hydroxy-6-methyl-5-(2-methylpropyl)-2H-pyran-2-yl-propyl]-Leu-Pip(hexahydro-3-pyridazinecarbonyl)-N-hydroxy-Ala-N-methyl-Phe-Pip-rho-lactone) with a site in the body tissue, wherein said agent comprises SEK-1005 in an amount which attracts immunosuppressive cells to the site in the body tissue to form the immune-tolerant site, wherein the body tissue is a subcutaneous tissue and wherein the immunosuppressive cells are regulatory T-cells or myeloid-derived suppressor cells.
A method for attracting immunosuppressive cells to a site in a body tissue comprising:
- contacting an agent comprising SEK-1005 with the site in the body tissue,
- wherein said agent comprises SEK-1005 in an amount which attracts the immunosuppressive cells to the site,
- wherein the body tissue is a subcutaneous tissue, and
- wherein the immunosuppressive cells are regulatory T-cells or myeloid-derived suppressor cells.
Dependencies are inferred from the claim text.