Composition of wood ear, shiitake, hawthorn fruit, roselle, celery and fruit of chinese plum for treatment and/or prevention of hyperlipidemia, atherogenesis and obesity

A water extract of a composition comprising wood ear (Auricularia auricular), shiitake (Lentinus edodes), hawthorn fruit (Crataegus pinnatifida), roselle (Hibiscus sabdariffa), celery (Apium graveolens) and fruit of Chinese plum (Prunus mume), wherein the water extract is obtained by mixing wood ear, shiitake, hawthorn fruit, roselle, celery and fruit of Chinese plum to form a composition, soaking the composition in water for at least 16 hours at a temperature of about 50° C. to about 80° C. and boiling the resulting composition to obtain the water extract of the composition;

• wherein the wood ear, shiitake, hawthorn fruit, roselle, celery and fruit of Chinese plum in the composition are in a ratio of about 0.5 to about 1.5:about 0.5 to about 1.5:about 1.5 to about 2.5:about 1.5 to about 2.5:about 4.5 to about 5.5:about 0.5 to about 1.5, respectively, by dry weight;
• and
• wherein the composition comprises compounds having retention times at about 3.2 to about 4.5 minutes and about 5.4 to about 6.2 minutes, respectively, as measured by HPLC;
• wherein the composition comprises compounds having retention times at about 4.61 minutes to 4.95 minutes, about 6.1 minutes to about 6.5 minutes, about 6.8 minutes to about 7.0 minutes, about 3.45 minutes to about 3.62 minutes and about 2.96 minutes to 3.16 minutes, respectively as measured by Extracted ion chromatogram (XIC) of multiple reaction monitoring (MRM), wherein the XIC of −MRM is detected at 153.000/109.000 Da of HPLC-MS/MS and protocatechuic acid is used as standard;
• or
• wherein the composition comprises compounds having retention times at about 4.35 minutes to about 4.65 minutes, about 3.41 minutes to about 3.62 minutes, about 4.0 minutes to about 4.15 minutes, about 3.8 minutes to about 4.0 minutes and about 5.18 minutes to about 5.4 minutes, respectively as measured by Extracted ion chromatogram (XIC) of multiple reaction (MRM), wherein the XIC of −MRM is detected at 153.000/109.000 Da of HPLC-MS/MS and chlorogenic acid is used as standard.