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AssigneesCity of Hope, The University of Chicago, University of Alabama at Birmingham
InventorsKaren S. Aboody, Alexander J. Annala, David Curiel, Maciej Lesniak
Estimating the term…
In some embodiments, methods of killing tumor cells are provided. The methods may include contacting the tumor cell with a tropic cell that carries a modified oncolytic virus, wherein the virus comprises a tumor selective element and/or a capsid protein that binds a tumor-specific cell surface molecule. In another embodiment, methods of treating cancer are provided. The methods may include administering a therapeutically effective amount of a pharmaceutical composition to a subject, wherein the pharmaceutical composition includes a tropic cell that carries a modified oncolytic virus, wherein the virus comprises a tumor selective promoter element and/or a capsid protein that binds a tumor-specific cell surface molecule.
A method of killing a tumor cell comprising:
A method of killing a brain tumor cell comprising contacting the brain tumor cell with a neural stem cell that carries a modified conditionally replicating adenovirus (CRAd) which comprises a tumor selective promoter element and/or a fiber protein that binds heparan sulfate proteoglycans, wherein the neural stem cell is from a neural stem cell line HB1.F3-CD.
A method of treating cancer comprising administering, to a subject, a therapeutically effective amount of a pharmaceutical composition which comprises a tropic cell that carries a modified oncolytic virus, wherein the virus comprises a tumor selective promoter element and/or a capsid protein that binds a tumor-specific cell surface molecule, and wherein the tropic cell is a stem cell from a neural stem cell line HB1.F3-CD.
Dependencies are inferred from the claim text.