Lactococcus lactis producing TSLP or IL-25 and their uses as probiotics and therapeutics
AssigneeAres Trading S.A.
InventorsPhilippe Langella, Jean-Marc Chatel, Luis Bermudez-Humaran, Camille Aubry, Laurence Goffin, Simone Favre-Zimmerli, Yolande Chvatchko
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Abstract
The present invention relates to recombinant Lactococcus lactis bacteria expressing and secreting TSLP or IL-25 or a combination thereof, and their use as probiotics or therapeutic agents, especially for use in the treatment of inflammatory diseases and disorders.
Claims8
A recombinant Lactococcus lactis bacterium, wherein the bacterium comprises an expression cassette comprising a heterologous nucleotide sequence encoding a cytokine selected from the group consisting of thymic stromal lymphopoietin (TSLP) and interleukin-25 (IL-25), wherein the heterologous nucleotide sequence encoding the cytokine is under the control of a promoter of the GroESL operon of Lactococcus lactis.
Dependencies are inferred from the claim text.