Spinal disc regenerative composition and method of manufacture and use
AssigneeVivex Biomedical, Inc.
InventorHarry Thomas Temple
Life of this patent
Estimating the term…
Abstract
The present invention provides a novel way to replenish the disc using retooled disc compositions to repair degenerative discs. There is no better source of proteoglycans than the actual disc material (6) itself. To this end, there has been developed a technique to remove the nucleus pulposus and retool the morphology of the nucleus pulposus to create a powder material (10) that is dry and can be stored at room temperature for long periods of time. This powder (10) can then be reconstituted with a variety of fluids, the most suitable being normal saline or lactated ringers to form a flowable mixture (20).
Claims4
An aqueous spinal disc regenerative composition suitable for injection, wherein the aqueous composition comprises a rehydrated micronized freeze-dried nucleus pulposus wherein the rehydrated micronized freeze-dried nucleus pulposus is
- a hydrated composition comprising freeze-dried micronized nucleus pulposus in a fluid, produced by a method consisting of:
- (i) providing the normal human cadaveric intervertebral discs;
- (ii) separating the nucleus pulposus from the annulus fibrosus of the normal human cadaveric intervertebral disc;
- (iii) drying the nucleus pulposus;
- (iv) micronizing the dried nucleus pulposus by pulverizing in a cryomill into particles sized less than 400 microns;
- (v) freeze-drying the nucleus pulposus, wherein said freeze-drying occurs during step (iii), between steps (iii) and (iv), and/or after step (iv);
- and then
- (vi) mixing the freeze-dried micronized nucleus pulposus with the fluid thereby producing the hydrated composition.
Dependencies are inferred from the claim text.