Treatment of filarial diseases

A method of preventing or treating filariasis caused by Onchocerca volvulus, Wuchereria bancrofti, Brugia malayi, Brugia timori, or Dirofilaria immitis in a subject in need thereof, comprising:

• administering to the subject a therapeutically effective amount of a compound of Formula (I):
• or a salt thereof, wherein:
• R1 represents hydrogen or —C(O)R3, wherein R3 represents an optionally substituted C1-C6-alkyl or C1-C6-haloalkyl;
• R2 represents —C(O)C(R4)(R5)(R6), wherein R4is selected from the group consisting of hydrogen, C1-C6-alkyl, C1-C6-haloalkyl, aryl, heteroaryl, C3-C8-cycloalkyl, heterocycloalkyl, arylalkyl, heteroarylalkyl, and C3-C8-cycloalkyl C1-C4-alkyl;
• and each of R5 and R6 are independently selected from the group consisting of C1-C6-alkyl, C1-C6-haloalkyl, aryl, heteroaryl, C3-C8-cycloalkyl, heterocycloalkyl, arylalkyl, heteroarylalkyl, and C3-C8-cycloalkyl -C1- C4-alkyl;
• or
• R2 represents —C(O)N(R7)(R8), wherein each of R7 and R8 are independently selected from the group consisting of hydrogen, C1-C6-alkyl, C1-C6-haloalkyl, aryl, heteroaryl, C3-C8-cycloalkyl, heterocycloalkyl, arylalkyl, heteroarylalkyl, and C3-C8-cycloalkyl -C1- C4-alkyl, or R7 and R8 together with the nitrogen atom to which they are attached form an optionally substituted saturated or partially saturated heterocyclic ring;
• or
• R2 represents —CH2-A1 , wherein A1 represents a 6-to 10-membered aryl or a 5-to 10-membered heteroaryl and A1 is unsubstituted or substituted with one or more RA, wherein each RA is independently selected from the group consisting of halogen, C1-C6-alkyl, C1-C6-haloalkyl, and —O —R9, where R9 represents C1-C6-alkyl;
• R10 represents hydrogen or —C(O)R11, wherein R11 represents an optionally substituted C1-C6-alkyl, C1-C6-haloalkyl, aryl, heteroaryl, C3-C8-cycloalkyl, heterocycloalkyl, arylalkyl, heteroarylalkyl, or C3-C8-cycloalkyl —C1- C4-alkyl;
• and
• each of a and b independently represents either a single bond or a double bond.

A method of preventing or treating filariasis caused by Onchocerca volvulus, Wuchereria bancrofti, Brugia malayi, Brugia timori, or Dirofilaria immitis in a subject in need thereof, comprising:

• administering to the subject a therapeutically effective amount of a compound of Formula (III):
• or a salt thereof, wherein:
• R1 represents hydrogen or —C(O)R3, where R3 represents C1-C6-alkyl;
• A1 represents a 6 -to 10-membered aryl or a 5 -to 10-membered heteroaryl and A1 is unsubstituted or substituted with one or more RA, wherein each RA is independently selected from the group consisting of halogen, C1-C6-alkyl, C1-C6-haloalkyl, and —O —R9,where R9represents C1-C6-alkyl;
• and
• each of a and b independently represents either a single bond or a double bond.