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US 10,238,671 B2Granted
Hydrosoluble hydroxybisphosphonic derivatives of doxorubicin
AssigneeAtlanthera
InventorsMaxim Egorov, Jean-Yves Goujon, Ronan Le Bot, Emmanuelle David
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Abstract
The invention relates to hydrosoluble hydroxybisphosphonic derivatives of doxorubicin of formula (I) and the pharmaceutically acceptable salts thereof. The invention also relates to the use of said compounds as a drug, especially in the treatment of a bone tumour. The invention further relates to the pharmaceutical compositions comprising such compounds, the methods for the synthesis thereof and synthesis intermediates.
Claims12
A compound of the following general formula (I):
- or a pharmaceutically acceptable salt thereof,
- wherein X represents a bivalent group selected from:
- with n and m each independently representing an integer between 1 and 6,
- with p and q each independently representing an integer between 1 and 6, and
- with t representing an integer between 1 and 6,
- these groups being bound to the imine function of the compound of formula (I) via their terminal nitrogen or oxygen atom and to the hydroxybisphosphonic acid function of the compound of formula (I) via their terminal carbon atom.
3 more elements
Dependencies are inferred from the claim text.