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US 10,238,668 B2Granted
Co-crystals of tramadol and coxibis
AssigneeLaboratorios Del Dr. Esteve, S.A.
InventorsCarlos Ramon Plata Salaman, Nicolas Tesson
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Abstract
The present invention relates to co-crystals of tramadol and co-crystal formers selected from NSAIDs/coxibs, processes for preparation of the same and their uses as medicaments or in pharmaceutical formulations, more particularly for the treatment of pain.
Claims6
A co-crystal comprising (rac)-tramadol.HCl and celecoxib in a molecular ratio of 1:1, characterized in that it shows a Powder X-Ray Diffraction pattern with peaks [2θ] at 14.1, 16.8, 19.0 and 22.7[°], with the 2θ values being obtained using copper radiation (CuKα1 1.54060Å).
Dependencies are inferred from the claim text.