Vitamin D receptor/SMAD genomic circuit gates fibrotic response
AssigneesThe Salk Institute for Biological Studies, The University of Sydney
InventorsNing Ding, Michael Downes, Christopher Liddle, Ronald M. Evans, Nanthakumar Subramaniam
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Abstract
The present disclosure provides compositions that include a nanoparticle and a compound that increases the biological activity of the vitamin D receptor (VDR) (e.g., a VDR agonist), and methods of using such compounds to increase retention or storage of vitamin A, vitamin D, and/or lipids by a cell, such as an epithelial or stellate cell. Such methods can be used to treat or prevent fibrosis.
Claims16
A method for increasing or retaining vitamin A, vitamin D, and/or lipid in an epithelial or stellate cell, comprising:
- contacting a therapeutically effective amount of a composition with the epithelial or stellate cell, wherein the composition comprises:
- a nanoparticle comprising retinol palmitate on its surface;
- and
- a vitamin D receptor (VDR) agonist, which is in or attached to the nanoparticle, thereby increasing or retaining vitamin A, vitamin D, and/or lipid in the epithelial or stellate cell.
A method for treating pancreatic fibrosis in a subject, comprising:
- administering to the subject a therapeutically effective amount of a composition comprising
- a nanoparticle comprising retinyl palmitate on its surface,
- paclitaxel, which is in or attached to the nanoparticle, and
- calcipotriol, which is in or attached to the nanoparticle,
- thereby treating the pancreatic fibrosis in the subject.
Dependencies are inferred from the claim text.