Extended-release drug delivery compositions
AssigneeOrbis Biosciences, Inc.
InventorsNathan Dormer, Cory Berkland
Life of this patent
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Abstract
An extended-release drug delivery composition and method of administering the same is provided. The composition comprises microspheres loaded with a biologically-active agent and suspended in a soluble polymer capable of forming a film upon injection onto a biological surface.
Claims12
A method for providing an extended-release treatment to a subject, the method comprising injecting a composition onto a biological tissue of the subject suffering from sensorineural hearing loss no more than one time in a 14 day period, wherein the composition comprises a biologically-active agent dispersed in a film-forming agent, wherein the film-forming agent comprises water and polyvinyl alcohol (PVA), wherein the PVA is from about 5% to about 10% w/v of the film-forming agent, wherein the PVA has a molecular weight of 20,000 to 30,000 Daltons, wherein the film-forming agent is free of solvent.
A method for providing an extended-release treatment to a subject, the method comprising injecting a composition onto a middle ear tissue of the subject no more than one time in a 14 day period, wherein the composition comprises a biologically-active agent dispersed in a film-forming agent, wherein the film-forming agent comprises water and polyvinyl alcohol (PVA), wherein the PVA is from about 5% to about 10% w/v of the film-forming agent, wherein the PVA has a molecular weight of 20,000 to 30,000 Daltons, and wherein the film-forming agent is free of solvent.
A method for providing an extended-release treatment to a subject, the method comprising injecting a composition onto a biological tissue of the subject no more than one time in a 14 day period, wherein the step of injecting the composition is performed by an intratympanic injection, wherein the composition comprises a biologically-active agent dispersed in a film-forming agent, wherein the film-forming agent comprises water and polyvinyl alcohol (PVA), wherein the PVA is from about 5% to about 10% w/v of the film-forming agent, wherein the PVA has a molecular weight of 20,000 to 30,000 Daltons, and wherein the film-forming agent is free of solvent.
Dependencies are inferred from the claim text.