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US 10,238,655 B2Granted
Dihydroindene and tetrahydronaphthalene compounds
AssigneeArizona Board of Regents on behalf of Arizona State University
InventorsCarl E. Wagner, Pamela A. Marshall, Peter W. Jurutka
Life of this patent
Estimating the term…
Abstract
The invention provides compounds of formula I: and salts thereof, as well as pharmaceutical compositions comprising such compounds. The compounds are useful for treating cancers, Alzheimer's disease, and conditions associated with demyelination.
Claims11
A compound of formula Ia:
- wherein:
- D is
- RN is (C3-C6)cycloalkyl, or (C2-C6)alkynyl, wherein the (C3-C6)cycloalkyl, and (C2-C6)alkynyl are optionally substituted with one or more groups independently selected from halo, hydroxy, nitro, and cyano;
- R2 is —COOH, —B(OH)2, or —SO3H;
- ring A is phenyl or 6-membered heteroaryl;
- each RA is independently selected from the group consisting of halo, hydroxy, cyano, nitro, (C1-C6)alkyl, (C3-C6)cycloalkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, (C1-C6)alkoxy, (C1-C6)alkoxycarbonyl, and (C1-C6)alkanoyloxy, wherein the (C1-C6)alkyl, (C3-C6)cycloalkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, (C1-C6)alkoxy, (C1-C6)alkoxycarbonyl, and (C1-C6)alkanoyloxy are optionally substituted with one or more groups independently selected from halo, hydroxy, nitro, cyano, (C1-C6)alkoxy, and oxo (═O);
- each RB is independently selected from the group consisting of halo, hydroxy, cyano, nitro, (C1-C6)alkyl, (C3-C6)cycloalkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, (C1-C6)alkoxy, (C1-C6)alkoxycarbonyl, and (C1-C6)alkanoyloxy, wherein the (C1-C6)alkyl, (C3-C6)cycloalkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, (C1-C6)alkoxy, (C1-C6)alkoxycarbonyl, and (C1-C6)alkanoyloxy are optionally substituted with one or more groups independently selected from halo, hydroxy, nitro, cyano, (C1-C6)alkoxy, and oxo (═O);
- n is 0, 1, 2, 3, or 4;
- and
- m is 0, 1, 2, or 3;
- or a salt thereof.
8 more elements
A compound of formula I:
- wherein:
- p is 0 and D is
- or p is 1 and D is
- RN is (C3-C6)cycloalkyl, or (C2-C6)alkynyl, wherein the (C3-C6)cycloalkyl, and (C2-C6)alkynyl are optionally substituted with one or more groups independently selected from halo, hydroxy, nitro, and cyano;
- R2 is —COOH, —B(OH)2, or —SO3H;
- ring A is
- each RA is independently selected from the group consisting of halo, hydroxy, cyano, nitro, (C1-C6)alkyl, (C3-C6)cycloalkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, (C1-C6)alkoxy, (C1-C6)alkoxycarbonyl, and (C1-C6)alkanoyloxy, wherein the (C1-C6)alkyl, (C3-C6)cycloalkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, (C1-C6)alkoxy, (C1-C6)alkoxycarbonyl, and (C1-C6)alkanoyloxy are optionally substituted with one or more groups independently selected from halo, hydroxy, nitro, cyano, (C1-C6)alkoxy, and oxo (═O);
- each RB is independently selected from the group consisting of halo, hydroxy, cyano, nitro, (C1-C6)alkyl, (C3-C6)cycloalkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, (C1-C6)alkoxy, (C1-C6)alkoxycarbonyl, and (C1-C6)alkanoyloxy, wherein the (C1-C6)alkyl, (C3-C6)cycloalkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, (C1-C6)alkoxy, (C1-C6)alkoxycarbonyl, and (C1-C6)alkanoyloxy are optionally substituted with one or more groups independently selected from halo, hydroxy, nitro, cyano, (C1-C6)alkoxy, and oxo (═O);
- n is 0, 1, 2, 3, or 4;
- and
- m is 0, 1, 2, or 3;
- or a salt thereof.
9 more elements
A compound selected from the group consisting of:
- and salts thereof.
Dependencies are inferred from the claim text.