Benzamides-containing compounds and their use in the treatment of epilepsy

A method of treating seizures mediated by P2X7 comprising administering a therapeutically P2X7 inhibiting effective amount of at least one compound of formula I

• wherein R1 is pyridyl, pyrazinyl, pyridazinyl, or pyrimidyl, each of which is optionally substituted with one or more C1-6 alkyl, halogen, hydroxy, C1-6 hydroxyalkyl, C1-4 fluoroalkyl, C3-6 cycloalkyl, C1-4 alkoxy, C1-4 fluoroalkoxy, cyano or —SO2R8;
• wherein R2 is C3-6 cycloalkyl, C3-6 cyclohetalkyl, C1-4 fluoroalkyl, C1-4 fluoroalkoxy, C1-4 alkoxy, C1-6 alkenyl, C1-6 alkynyl, 6 membered heteroaryl, phenyl or C1-4 alkyl optionally substituted with one or more R9;
• wherein R3 is hydrogen, fluorine, C1-4 alkyl or C1-4 fluoroalkyl;
• or
• wherein R2 and R3 combine with the carbon to which they are attached to form cyclohexyl, tetrahydropyranyl, piperazinyl, piperidinyl, morpholinyl, pyrrolidinyl, pyrrolo, imidazo, azetidinyl, homomorpholinyl, homopiperidinyl or homopiperazinyl each of which is optionally substituted with one or more C1-6 alkyl, C1-6 alkenyl, C3-6-cycloalkyl, C1-6 alkoxy, oxo, —NR6R7 or fluorine;
• wherein R4 is halogen, C1-4 fluoroalkyl, cyano, cyclopropyl, C1-4alkyloxy, C1-4 fluoroalkyloxy, —SO2R8, —NR6R7 or C1-6 alkyl;
• wherein R5 is halogen, C1-6 alkyl, C1-4 fluoroalkyl, cyano, —SO2R8, —NR6R7, C1-6 alkoxy, C1-4 fluoroalkoxy or C3-6 cycloalkyl;
• wherein R6 and R7 independently of each other are hydrogen or C1-6 alkyl;
• wherein R8 is C1-6 alkyl, C3-6 cycloalkyl or C1-4 fluoroalkyl;
• wherein R9 is C1-6 alkyl, C3-6 cycloalkyl, —NR10C1-4 fluoroalkyl or 3 to 7 membered heterocyclyl which is optionally substituted with one or more C1-6 alkyl, halogen, hydroxy, C1-4 fluoroalkyl, C3-6 cycloalkyl, C1-4 alkoxy, C1-4 fluoroalkoxy or cyano;
• wherein R10 and R11 independently of each other are hydrogen or C1-6 alkyl;
• or
• wherein R10 and R11 combine with the nitrogen to which they are attached to form piperazinyl, piperidinyl, morpholinyl, pyrrolidinyl, azetidinyl, homomorpholinyl, homopiperidinyl or homopiperazinyl each of which is optionally substituted with one or more C1-6 alkyl, C1-6 alkoxy, oxo or fluorine;
• and
• wherein n is 0-3;
• or a pharmaceutically acceptable salt thereof;
• to a subject in need thereof.