Use of masitinib for treatment of cancer in patient subpopulations identified using predictor factors
AssigneeScience Incorporated
InventorsAlain Moussy, Jean-Pierre Kinet
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AssigneeScience Incorporated
InventorsAlain Moussy, Jean-Pierre Kinet
Estimating the term…
A method for treating patients afflicted with cancer, wherein the patients are treated with a compound including tyrosine kinase inhibitor, mast cell inhibitor or c-Kit inhibitor, in particular masitinib, optionally in combination with at least one antineoplastic agent. The tyrosine kinase inhibitor, mast cell inhibitor or c-Kit inhibitor, and the optional at least one antineoplastic agent, are administered in a dosage regimen that includes a therapeutically effective amount. Also described are methods for predicting therapeutic response to the treatment in a given patient and therefore identification of applicable patient subpopulations based upon these predictor factors; sometimes referred to as biomarkers. One method is based upon the clinical marker of pain intensity. Another method is based upon gene expression predictive biomarkers assessed via RNA expression in peripheral blood cell samples collected prior to treatment with the compound, which is also used for treating patients afflicted with pancreatic cancer.
A method for the treatment of pancreatic cancer in a human patient suffering from disease related pain intensity determined to be greater than 20% with a unidimensional pain intensity assessment tool, said method comprising:
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