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US 10,238,643 B2Granted
Methods and compositions for treatment of disorders ameliorated by muscarinic receptor activation
AssigneePureTech Health LLC
InventorsEric Elenko, Philip E. Murray, III, Andrew C. Miller
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Abstract
Methods for the treatment of CNS disorders using combinations of muscarinic activators and inhibitors, and medicaments comprising muscarinic activators and inhibitors.
Claims16
An oral medicament comprising:
- (a) between 25 mg and 700 mg xanomeline and/or a salt thereof used during a 24-hour period;
- (b) between 5 mg and 200 mg trospium chloride used during a 24-hour period;
- and
- (c) a pharmaceutically acceptable carrier;
- wherein use of the trospium chloride alleviates a side effect associated with use of the xanomeline.
2 more elements
Dependencies are inferred from the claim text.