N-carbamoylated urethane for treating a neuroinflammatory disease
AssigneeKyungpook National University Industry-Academic Cooperation Foundation
InventorsKyoungho Suk, Gyun Jee Song, Youngpyo Nam, Myungjin Jo
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Abstract
There is provided a composition for treating a neuroinflammatory disease comprising a N-carbamoylated urethane compound which has an effect of inhibiting the activity of microglia or astrocytes and the production of nitric oxide (NO) and TNF-α, and suppressing the expression of IL-1β And iNOS genes. There is also provide a method for treating a neuroinflammatory disease, the method comprising the step of administering a N-carbamoylated urethane compound. Due to its above mentioned effects, the N-carbamoylated urethane compound according to the present invention can be useful for the treatment of neuroinflammatory diseases.
Claims3
A method for treating a neuroinflammatory disease, the method comprising the step of administering a compound represented by Chemical Formula 1 or a pharmaceutically acceptable salt thereof in an amount effective to treat a neuroinflammatory disease in a subject:
- wherein
- n is 1 or 2,
- R is selected from the group consisting of C1-C4 alkoxy, C1-C4 alkyl unsubstituted or substituted by halogen, halogen, hydrogen, and 3,4-methylenedioxy, and
- wherein the neuroinflammatory disease is selected from the group consisting of inflammatory brain disease, multiple sclerosis, Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis.
Dependencies are inferred from the claim text.