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US 10,238,629 B2Granted
Methods for reducing the occurrence of hot flashes
AssigneeOhio State Innovation Foundation
InventorsChandan K. Sen, Sashwati Roy, Savita Khanna, Cameron Rink
Life of this patent
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Abstract
The present invention provides methods to reduce the number and severity of hot flashes utilizing tocotrienols. In particular, symptoms of perimenopause and menopause may be treated using the present methods. The present invention also provides methods to increase tissue concentrations of tocotrienols.
Claims8
A method to ameliorate one or more symptoms of perimenopause or menopause in a subject having perimenopause or menopause, or to ameliorate hot flashes in a subject receiving androgen deprivation therapy, comprising:
- a) administering to the subject having symptoms of perimenopause or menopause, or to the subject receiving androgen deprivation therapy, a tocotrienol formulation comprising at least 10% alpha-tocopherol, at least 12% alpha-tocotrienols, at least 20.6% gamma-tocotrienols, at least 1.5% beta-tocotrienols, and at least 5% delta-tocotrienols;
- and
- b) ameliorating the symptoms of perimenopause or menopause in the subject having perimenopause or menopause, or ameliorating hot flashes in the subject receiving androgen deprivation therapy.
Dependencies are inferred from the claim text.