Compounds for treatment of angiogenesis-mediated diseases
AssigneeIndiana University Research and Technology Corporation
InventorsTimothy W. Corson, Halesha D. Basavarajappa, Seung-Yong Seo, Bit Lee, Xiang Fei
Life of this patent
Estimating the term…
Abstract
Synthetic cremastranone and cremastranone analogs are disclosed. Additionally, methods for synthesizing cremastranone and cremastranone analogs are disclosed. Methods of treating ocular neovascularization disorders and treating angiogenesis-mediated disease are also disclosed.
Claims11
A method of treating retinoblastoma in a subject in need thereof, the method comprising administering an effective amount of the compound of formula (I)
- wherein R1, R2, R3, R4, and R5 are independently selected from the group consisting of hydrogen, hydroxyl, alkoxy, substituted alkoxy, alkyl carbonyloxy, substituted alkyl carbonyloxy, alkyl carbonyl, substituted alkyl carbonyl, aryl carbonyloxy, substituted aryl carbonyloxy, halogen, amino, nitro, hydrocarbyl and substituted hydrocarbyl;
- and X, Y, and Z are independently selected from the group consisting of carbon, nitrogen, and oxygen.
A method of treating retinoblastoma in a subject in need thereof, the method comprising administering an effective amount of the compound of formula (VI)
- wherein R1, R2, R3, R4, and R5 are independently selected from the group consisting of hydrogen, hydroxyl, alkoxy, substituted alkoxy, alkyl carbonyloxy, substituted alkyl carbonyloxy, alkyl carbonyl, substituted alkyl carbonyl, aryl carbonyloxy, substituted aryl carbonyloxy, halogen, amino, nitro, hydrocarbyl and substituted hydrocarbyl;
- and R6 is selected from the group consisting of hydrogen and substituted hydrocarbyl, and a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.