Methods of treating and preventing/reducing the likelihood of Mesial temporal lobe epilepsy (TLE)
OwnerWolfgang S. Mueller, John A. Connor +2inventors
InventorsWolfgang S. Mueller, John A. Connor, Steven Peterson, Denis Bragin
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Abstract
The invention provides methods of treatment that prevent the onset of Mesial temporal lobe epilepsy (TLE) in a subject, or which reduce the severity of TLE in a subject, by administering a NKCC1 inhibitor to the subject after the subject has suffered from an insult known to precipitate TLE.
Claims11
A method of inhibiting or reducing the severity of Mesial temporal lobe epilepsy (TLE) in a subject, the method comprising administering a therapeutically effective amount of a NKCC1 inhibitor to the subject within two to four weeks or eight to twenty-four weeks after the subject has suffered from an insult known to precipitate TLE;
- wherein said NKCC1 inhibitor is a loop diuretic or a pharmaceutically acceptable salt or ester thereof, or an inhibitor of re-expression of NKCC1, and wherein the inhibitor of re-expression of NKCC1 is not a GABA modulator.
Dependencies are inferred from the claim text.