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US 10,238,620 B2Granted
Methods of using low-dose doxepin for the improvement of sleep
AssigneesPernix Sleep, Inc., ProCom One, Inc.
InventorsRoberta L. Rogowski, Susan E. Dubé, Philip Jochelson, Neil B. Kavey
Life of this patent
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Abstract
Methods of preventing early awakenings, and improving sleep efficiency in hours 7 and 8 of a period of sleep, by administration of low doses of doxepin (e.g., 1-6 mg).
Claims20
A method for treating insomnia, the method comprising:
- administering an oral formulation comprising doxepin or a pharmaceutically acceptable salt thereof to a patient having a sleep disorder in which, for a given 8 hour period of desired sleep, the patient experiences fragmented sleep during the final 60 minutes of said period, wherein the oral formulation comprises a dosage of doxepin between about 1 and about 7 mg and is administered prior to bedtime.
A method for treating insomnia, the method comprising:
- administering an oral formulation comprising doxepin or a pharmaceutically acceptable salt thereof to a patient having a sleep disorder in which, for a given 8 hour period of desired sleep, the patient experiences early awakenings during the final 60 minutes of said period, wherein the oral formulation comprises a dosage of doxepin between about 1 and about 7 mg and is administered prior to bedtime.
Dependencies are inferred from the claim text.