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US 10,238,615 B2Granted
3,5,3′-triiodothyronine sulfate as thyromimetic agent and pharmaceutical formulations thereof
AssigneeBracco S.p.A.
InventorsLivio Cavalieri, Giovanni Rivolta, Fulvia Vella
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Abstract
The invention regards the use of triiodothyronine sulfate, commonly named T3S, as a medicament having thyromimetic activity for the treatment of pathologies due to organic deficiency of triiodothyronine (T3), as such or in association with thyroxine (T4), and pharmaceutical formulations for oral administration thereof.
Claims12
A stable daily dosage thyroid hormone composition comprising triiodothyronine sulfate (T3S) as the active principle, in a quantity ranging, from 1 to 1000 μg;
- a diluent consisting of:
- microcrystalline cellulose of the alpha type and calcium carbonate;
- a glidant consisting of:
- glycerol dibehenate;
- a lubricant consisting of:
- magnesium stearate and hydrate colloidal silica;
- and
- a disintegrant consisting of:
- croscarmellose or salts thereof.
6 more elements
Dependencies are inferred from the claim text.