Transdermal administration of tamsulosin
AssigneeCorium International, Inc.
InventorsParminder Singh, Eun Soo Lee, Amit K. Jain
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Abstract
In an aspect of the invention, a composition for making a patch for the transdermal delivery of tamsulosin is provided. The composition comprises (a) at least about 1 wt % tamsulosin or a pharmaceutically acceptable salt of tamsulosin, (b) at least about 40 wt % polyisobutylene adhesive or hydrophobic synthetic rubber adhesive, (c) about 1-20 wt % of an aprotic solvent in which tamsulosin dissolves readily, (d) about 1-20 wt % of an unsaturated fatty acid or an alpha-hydroxy acid or a mixture of unsaturated fatty acids or alpha-hydroxy acids or of both unsaturated fatty acids and alpha-hydroxy acids, (e) a lipophilic permeation enhancer, and (f) a matrix modifier.
Claims19
A method for treating a urological condition, comprising:
- providing a transdermal patch comprising an adhesive matrix comprised of polyisobutylene, a solvent selected from dimethylacetamide, n-methylpyrrolidone and dimethylsulfoxide, a mixture of an unsaturated fatty acid and an alpha-hydroxy acid, a permeation enhancer of the formula CH3(CH2)mOCOCHR1R2, where m is an integer in the range of 6 to 14, R1 and R2 are each independently selected from hydrogen, hydroxyl, and a C1-C2 lower alkyl group, wherein at least one of R1 and R2 is hydroxyl or both R1 and R2 are hydrogen, and tamsulosin;
- and
- administering or instructing to administer the transdermal patch.
A method for treating benign prostatic hyperplasia, comprising:
- providing a transdermal patch comprising an adhesive matrix comprised of polyisobutylene, a solvent selected from dimethylacetamide, n-methylpyrrolidone and dimethylsulfoxide, a mixture of an unsaturated fatty acid and an alpha-hydroxy acid, a permeation enhancer of the formula CH3(CH2)mOCOCHR1R2, where m is an integer in the range of 6 to 14, R1 and R2 are each independently selected from hydrogen, hydroxyl, and a C1-C2 lower alkyl group, wherein at least one of R1 and R2 is hydroxyl or both R1 and R2 are hydrogen, and tamsulosin;
- and
- administering or instructing to administer the transdermal patch.
Dependencies are inferred from the claim text.