Apparatus, method and computer-accessible medium for diagnosing and subtyping psychiatric diseases
AssigneeThe Trustees of Columbia University in the City of New York
InventorsRavi Bansal, Bradley S. Peterson
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Abstract
Exemplary method, system and computer-accessible medium can be provided for diagnosing at least one disease and/or a subtype within a disease. For example, it is possible to determine at least one region of interest, and obtain a plurality of data points associated with each of such region(s) of interest. It is also possible to identify a particular pattern of the data points across each of such region(s) of interest. Further, it is possible, e.g., using a computer arrangement, to determine a likelihood of the disease(s) and/or the subtype by comparing the particular pattern to at least one known pattern.
Claims43
A method for diagnosing at least one of (i) an attention deficit hyperactivity disorder, (ii) a bipolar disorder, (iii) a schizophrenia, or (iv) a major depressive disorder for at least one patient, comprising:
- (i) receiving a plurality of structural magnetic resonance (MR) images of a brain of the at least one patient;
- (ii) determining at least one region of interest of the brain of the at least one patient from the structural MR images;
- (iii) mapping the brain in the structural MR images to a template brain;
- (iv) extracting a cortical thickness measure across an entire surface of the brain of the at least one patient based on the template brain;
- (v) determining a plurality of first data points describing a plurality of morphological features for the at least one region of interest based on procedures (iii) and (iv);
- (vi) applying a wavelet transformation (WT) procedure to the first data points in order to generate a plurality of second data points, wherein the second data points are scaling coefficients;
- (vii) identifying a particular spatial pattern of the second data points across the at least one region of interest using the scaling coefficients;
- and
- (viii) using a computer arrangement, diagnosing the at least one of (i) the attention deficit hyperactivity disorder, (ii) the bipolar disorder, (iii) the schizophrenia, or (iv) the major depressive disorder for the at least one patient by comparing the particular spatial pattern for the at least one patient to at least one known spatial pattern.
A non-transitory computer readable medium including instructions thereon for diagnosing at least one of (i) an attention deficit hyperactivity disorder, (ii) a bipolar disorder, (iii) a schizophrenia, or (iv) a major depressive disorder, wherein when a computer arrangement executes the instructions, the computer arrangement is configured to perform procedures comprising :
- (i) receiving a plurality of structural magnetic resonance (MR) images of a brain of the at least one patient;
- (ii) determining at least one region of interest of the brain of the at least one patient from the structural MR images;
- (iii) mapping the brain of the at least one patient in the structural MR images to a template brain;
- (iv) extracting a cortical thickness measure across an entire surface of the brain of the at least one patient based on the template brain;
- (v) determining a plurality of first data points describing a plurality of morphological features for the at least one region of interest based on procedures (iii) and (iv);
- (vi) applying a wavelet transformation (WT) procedure to the first data points in order to generate a plurality of second data points, wherein the second data points are scaling coefficients;
- (vii) identifying a particular spatial pattern of the second data points across the at least one region of interest using the scaling coefficients;
- and
- (viii) diagnosing the at least one of (i) the attention deficit hyperactivity disorder, (ii) the bipolar disorder, (iii) the schizophrenia, or (iv) the major depressive disorder for the at least one patient by comparing the particular spatial pattern for the at least one patient to at least one known spatial pattern.
An apparatus for diagnosing at least one of (i) an attention deficit hyperactivity disorder, (ii) a bipolar disorder, (iii) a schizophrenia, or (iv) a major depressive disorder for at least one patient, comprising:
- a computer hardware arrangement configured to:
- (i) receive a plurality of structural magnetic resonance (MR) images of a brain of the at least one patient;
- (ii) determine at least one region of interest of the brain of the at least one patient from the structural MR images;
- (iii) map the brain of the at least one patient in the structural MR images to a template brain;
- (iv) extract a cortical thickness measure across an entire surface of the brain of the at least one patient of the at least one patient based on the template brain;
- (v) determine a plurality of first data points describing a plurality of morphological features for the at least one region of interest based on procedures (iii) and (iv);
- (vi) apply a wavelet transformation (WT) procedure to the first data points in order to generate a plurality of second data points, wherein the second data points are scaling coefficients;
- (vii) identify a particular spatial pattern of the second data points across the at least one region of interest using the scaling coefficients;
- and
- (viii) diagnose the at least one of (i) the attention deficit hyperactivity disorder, (ii) the bipolar disorder, (iii) the schizophrenia, or (iv) the major depressive disorder for the at least one patient by comparing the particular spatial pattern for the at least one patient to at least one known spatial pattern.
A method for diagnosing at least one of (i) an attention deficit hyperactivity disorder, (ii) a bipolar disorder, (iii) a schizophrenia, or (iv) a major depressive disorder for at least one patient, comprising:
- (i) receiving a plurality of structural magnetic resonance (MR) images of a brain of the at least one patient;
- (ii) determining at least one region of interest from the structural MR images;
- (iii) mapping the brain in the structural MR images to a template brain;
- (iv) extracting at least one of (a) a cortical thickness measure across an entire surface of the brain of the at least one patient based on the template brain or (b) a morphology of the at least one region of interest;
- (v) determining a plurality of data points describing a plurality of morphological features for the at least one region of interest based on (iii) and (iv);
- (vi) generating a plurality of scaling coefficients by reducing a quantity of the data points;
- identifying a particular spatial pattern across the at least one region of interest using the scaling coefficients;
- and
- using a computer hardware arrangement, diagnosing the at least one of (i) the attention deficit hyperactivity disorder, (ii) the bipolar disorder, (iii) the schizophrenia, or (iv) the major depressive disorder for the at least one patient by comparing the particular spatial pattern to at least one known spatial pattern.
Dependencies are inferred from the claim text.