Contact thermo-optical structure and its application for non-invasive imaging of histamine-induced hyperthermal subcutaneous reaction magnitude in cutaneous allergic reaction, recording device and method of allergic reaction diagnosis

A method of diagnosing skin allergic reactions induced by in vivo skin prick test (SPT) and skin patch test (PT) and by identification of hyperthermic allergic responses, the method comprising the steps of:

• applying respectively on a first region, a second region, and a third region of patient's skin:
• a positive control histamine solution having a minimum concentration of 1 mg/ml to obtain a positive control reaction,
• a negative control sodium chloride (NaCl) solution having a concentration of 0.9% to obtain a neutral or negative control reaction, and
• a standarized testing allergen solution to induce allergic skin responses to evaluate allergic reactions;
• measuring hyperthermic reactions in the first, second and third regions by identification of hyperthermic areas displayed on a screen of a planar thermosensitive detector;
• and
• comparing a size of the positive control reaction (histamine-induced hyperthermia in the first region) with a size of the neutral or negative control reaction (sodium chloride-induced hyperthermia in the second region) and a size of the allergic reactions (allergen-induced hyperthermia in the third region),
• wherein the comparing step is performed based upon an extent of color images displayed, in the measuring step, on the screen of the planar thermosensitive detector, said displayed color images being relevant to the hyperthermic areas revealed over patient's skin in the first, second and third regions.