Lipopolysaccharide-targeted peptide mimic vaccine against Q fever
AssigneeThe Curators of the University of Missouri
InventorGuoquan Zhang
Life of this patent
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Abstract
A vaccine and method of vaccination for conferring immunity to Q fever is described. The vaccine comprises a polypeptide with a sequence of SLTWHKHELHRK (SEQ ID NO: 7) (m1E41920) or SPPWHKHELHRK (SEQ ID NO: 8) (m1E44), or at least 90% identity to m1E41920 or m1E44. Constructs are also provided for use in vaccination and treatment of Q fever. A method to identify and generate new vaccines to prevent diseases caused by intracellular Gram-negative bacteria is also described.
Claims4
An antibody or fragment thereof that binds to a lipopolysaccharide-based epitope in gram negative bacteria, wherein the antibody or fragment thereof comprises the polypeptide sequence of SEQ ID NO:
- 5 or SEQ ID NO:6.
Dependencies are inferred from the claim text.