Anti-tumour response to modified self-epitopes
AssigneeScancell Limited
InventorsLinda Gillian Durrant, Victoria Anne Brentville, Rachael Louise Metheringham
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Abstract
Anti-tumor immune responses to modified self-epitopes. The present invention relates to the use of tumor-associated epitopes in medicine and in particular in the treatment of cancer. The epitopes stimulate an immune reaction against the tumor and have a modification selected from deimination of arginine to citrulline, nitration of tyrosine, oxidation of tryptophan and deamination of glutamine or asparagine. The invention also relates to nucleic acids comprising sequences that encode such epitopes for use in the treatment of cancer.
Claims10
A method of stimulating an immune response to a tumor that expresses a citrullinated tumor-associated MHC Class II CD4+ T-cell epitope in a subject in need thereof comprising administering to said subject a therapeutically effective amount of the citrullinated tumor-associated epitope which stimulates an immune reaction against the tumor, wherein the citrullinated tumor-associated epitope comprises at least one of the following sequences:
- (SEQ ID NO:
- 98)
- RSYVTTSTRTYSLGSALRPSTS (vim28-49),
- (SEQ ID NO:
- 59)
- SAVRLRSSVPGVR (vim65-77)
- (SEQ ID NO:
- 61)
- LPNFSSLNLRETNLDSLPL (vim415-433).
- wherein one or more of the R residues is substituted for citrulline.
A method of treating cancer in a subject in need thereof comprising administering to said subject a therapeutically effective amount of an epitope comprising the sequence YVTTSTRTYSLGSALR (SEQ ID NO:
- 55), optionally comprising the sequence RSYVTTSTRTYSLGSALRPSTS (vim28-49) (SEQ ID NO:
- 56), wherein the sequence of the epitope is less than that of the full length protein.
A method of stimulating an immune response to a tumor that expresses a citrullinated tumor-associated MHC Class II CD4+ T-cell epitope in a subject in need thereof comprising administering to said subject a therapeutically effective amount of the citrullinated tumor-associated epitope which stimulates an immune reaction against the tumor, wherein the citrullinated tumor-associated epitope is:
- YVTTSTRTYSLGSALR (SEQ ID NO:
- 55),
- wherein one or more of the R residues is substituted for citrulline.
Dependencies are inferred from the claim text.