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US 10,233,219 B2Granted
Methods and systems for designing and/or characterizing soluble lipidated ligand agents
AssigneesTufts Medical Center, Inc., Trustees of Tufts College, On Target Therapeutics LLC
InventorsCharles Cohen, Krishna Kumar, Jamie Raudensky Doyle, Alan S. Kopin
Life of this patent
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Abstract
The present application provides methods for preparing soluble lipidated ligand agents comprising a ligand entity and a lipid entity, and in some embodiments, provides relevant parameters of each of these components, thereby enabling appropriate selection of components to assemble active agents for any given target of interest.
Claims12
A soluble lipidated ligand agent comprising:
- a ligand entity comprising:
- (a) a human chemerin fragment having the sequence of YFPGQFAFS (SEQ ID NO.:
- 8) or
- (b) a chemerin analog having the sequence of YFLPSQFA-Tic-S(SEQ ID NO.:
- 10), wherein one or more of the amino acids are D-amino acids, and wherein Tic represents (S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid;
- at least one lipid entity covalently linked to the ligand entity at or near the N-terminus, at or near the C-terminus, or at or near both the N-terminus and C-terminus;
- and
- an optional linker entity connecting the ligand entity to the at least one lipid entity.
5 more elements
A soluble lipidated ligand agent having the following structure:
- wherein Tic represents (S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid, and wherein the GGYFLPSQFA-Tic-S is SEQ ID NO.:
- 11.
Dependencies are inferred from the claim text.