Process for preparation of glucocorticoid steroids
AssigneeCoral Drugs Pvt. Ltd.
InventorsVinayak Tripathi, Rajesh Kumar, Rohit Bhuwania, Binay Kumar Bhuwania
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Abstract
The present invention discloses a process for the preparation of 16, 17-acetals of pregnane derivatives having formula I wherein each substituent is independently selected from; R1 is H or CH3; R2 is C1-C6 linear or branched alkyl, alkynyl group or cycloalkyl group; aryl or heteroaryl group; or R1 and R2 combine to form saturated, unsaturated C3-C6 cyclic or heterocyclic ring; R3 and R4 are same or different and each independently represents H or halogen; R5 is —OH or —OCOR wherein R represents H or C1-C6 linear, branched or cyclic alkyl group that may be substituted.
Claims20
A process for the preparation of 16,17-acetals of pregnane derivatives having formula (I)
- wherein:
- R1 is H or CH3;
- R2 is C1-C6 linear or branched alkyl, alkynyl group or cycloalkyl group, aryl or heteroaryl group;
- or
- R1 and R2 combine to form a saturated or unsaturated C3-C6 cyclic or heterocyclic ring;
- R3 and R4 are the same or different and each independently represents H or halogen;
- and
- R5 is —OH or —OCOR wherein R represents H or C1-C6 linear, branched or cyclic alkyl group that is optionally substituted;
- comprising the steps of:
- (i) dihydroxylation of the compound of formula II to obtain the compound of formula III;
- (ii) bromination of the compound of formula III to obtain the hydroxylated brominated compound of formula IV;
- (iii) debromination of the compound of formula IV to obtain the compound of formula V;
- (iv) deacetylation of the compound of formula V to obtain the compound of formula VI;
- and
- (v) alkylation of the compound of formula VI to obtain the compound of formula I.
Dependencies are inferred from the claim text.