Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds

A method of preparing a compound of Formula (I):

• or a salt thereof, the method comprising reacting a compound formula (2):
• or a salt thereof, with a compound of the formula:
• or a salt thereof, wherein:
• Ar is a moiety selected from the group of:
• X is selected from —CH2—, —O—, and —S—;
• n is an integer selected from 0, 1, 2, 3, 4, 5, and 6;
• R is a polyhydroxylated alkyl group having from 3 to 8 carbon atoms;
• R1 is selected from —(CH2)qY and —(CH2)q—O—Y;
• q is an integer selected independently in each instance from 1, 2, 3, 4, 5, and 6;
• and
• Y is a phenyl, naphthyl, or pyridyl ring, with each phenyl, naphthyl, or pyridyl ring substituted by 0, 1, 2, or 3 substituents independently selected from halogen, —OH, —CN, —NO2, —NH2, —NH(C1-C6 alkyl), —N(C1-C6 alkyl)2, C1-C6 alkyl, C1-C6 alkoxy, and —CF3.