Back to results
US 10,228,378 B2Granted
Diagnostic and therapeutic methods and products related to anxiety disorders
AssigneesUniversity of Vermont and State Agricultural College, Emory University
InventorsVictor May, Kerry J. Ressler, Sayamwong E. Hammack, Donna Toufexis, Karen M. Braas
Life of this patent
Estimating the term…
Abstract
The present disclosure provides methods for diagnosing and treating anxiety disorders in female subjects. Diagnosis and treatment of such anxiety disorders are based, in part, on an analysis of pituitary adenylate cyclase-activating polypeptide (PACAP) expression levels in tissue collected from female subjects.
Claims6
A method for diagnosing an anxiety disorder in a subject, comprising:
- a. collecting a DNA sample from the subject;
- b. analyzing the DNA sample for the presence of a SNP in a PAC1 receptor gene and/or for epigenetic methylation at a first site within a ADCYAP1R1 CpG island;
- c. diagnosing the anxiety disorder in the subject having the SNP in the PAC1 receptor gene and/or having elevated levels of epigenetic methylation;
- and
- d. administering a therapeutically effective amount of a PACAP inhibitor or PACAP receptor antagonist.
2 more elements
Dependencies are inferred from the claim text.