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US 10,227,664 B2Granted
Cedar virus and methods of use
AssigneesThe Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., The State of Queensland, Department of Agriculture, Fisheries and Forestry, Commonwealth Scientific and Industrial Research Organization
InventorsLinfa Wang, Glenn A. Marsh, Hume Field, Christopher Broder
Life of this patent
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Abstract
The present invention is directed towards a novel virus, called Cedar Virus, and its methods of use.
Claims14
A method of identifying an agent for inhibiting Hendra virus (HeV) or Nipah virus (NiV) infection, the method comprising
- (a) treating an in vitro population of cells with Cedar Virus (CedV) and the agent, and
- (b) determining the growth response of the treated cells,
- wherein the agent is identified as a potential inhibitor of HeV or NiV infection when proliferation of the cells treated with the agent increases compared to the proliferation of untreated CedV infected cells.
A method of identifying an agent for inhibiting Hendra virus (HeV) or Nipah virus (NiV) infection, the method comprising
- (a) treating an in vitro population of cells with Cedar Virus (CedV) and the agent, and
- (b) determining the cytopathic effect (CPE) in the treated cells,
- wherein the lack of a CPE in the treated cells is indicative that the agent potentially reduces the ability of HeV or NiV to infect a subject when the subject is exposed to HeV or NiV.
Dependencies are inferred from the claim text.