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US 10,227,629 B2Granted
Diagnosis and treatment of invasive aspergillosis
AssigneeThe Brigham and Women's Hospital, Inc.
InventorsSophia Koo, Horatio R. Thomas, Lindsey R. Baden, Francisco M. Marty
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Abstract
Methods for diagnosing, treating, and monitoring the treatment of invasive aspergillosis (IA) are described. The methods can include detecting the presence of one or more volatile organic compounds (VOCs) in the breath of subjects suspected of having IA.
Claims14
A method for diagnosing a subject with invasive aspergillosis (IA), the method comprising:
- obtaining a sample comprising breath of a subject;
- detecting the presence in the sample of two or more volatile organic compounds (VOCs) produced by the Aspergillus species in the sample, wherein the VOCs are selected from the group consisting of α-trans-bergamotene, β-trans-bergamotene, and trans-geranylacetone;
- and
- diagnosing a subject as having IA who has the two or more VOCs present in the sample.
1 more element
A method comprising:
- obtaining a sample comprising breath of a subject or headspace from a culture suspected of comprising Aspergillus isolated from a subject;
- and
- detecting the presence in the sample of two or more volatile organic compounds (VOCs) produced by the Aspergillus species in the sample, wherein the two or more VOCs are selected from the group consisting of α-trans-bergamotene, β-trans-bergamotene, and trans-geranylacetone, and optionally detecting the presence in the sample of VOCs selected from the group consisting of camphene, α-pinene, β-pinene, and limonene.
Dependencies are inferred from the claim text.