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US 10,227,569 B2Granted
Respiratory syncytial virus expression vectors
AssigneesEmory University, Children's Healthcare of Atlanta, Inc.
InventorsMartin L. Moore, Anne Hotard
Life of this patent
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Abstract
In certain embodiments, the disclosure relates to vectors containing bacterial nucleic acid sequences and a paramyxovirus gene. Typically, the expression vector comprises a bacterial artificial chromosome (BAC), and a nucleic acid sequence comprising a respiratory syncytial virus (RSV) gene in operable combination with a regulatory element and optionally a reporter gene.
Claims10
A vector comprising
- a) a bacterial artificial chromosome comprising oriS, repE, parA, and parB genes of Factor F, and
- b) a nucleic acid sequence comprising a respiratory syncytial virus (RSV) antigenome
- wherein the vector comprises restriction sites BstBI, SacI, ClaI, and MluI in that order.
A vector comprising
- a) a bacterial artificial chromosome comprising oriS, repE, parA, and parB genes of Factor F, and
- b) a nucleic acid sequence comprising a respiratory syncytial virus (RSV) antigenome in operable combination with a reporter gene
- wherein the vector comprises restriction sites BstBI, SacI, ClaI, and MluI in that order.
Dependencies are inferred from the claim text.