Heterodimeric antibodies that bind CD3 and PSMA

A heterodimeric antibody comprising:

• a) a first monomer comprising:
• i) a first Fc domain;
• and
• ii) an anti-CD3 scFv comprising a first heavy variable domain, an scFv linker and a first variable light domain;
• wherein said scFv is covalently attached to the N-terminus of said Fc domain using a domain linker;
• b) a second monomer comprising a heavy chain comprising:
• i) a second heavy variable domain;
• and
• ii) a heavy constant domain comprising a second Fc domain;
• and
• c) a light chain comprising a second variable light domain and a constant light domain;
• wherein said second heavy variable domain comprises a vhCDR1 having SEQ ID NO:
• 111, a vhCDR2 having SEQ ID NO:
• 112, and a vhCDR3 having SEQ ID NO:
• 113,
• and said second variable light domain comprises a vlCDR1 having SEQ ID NO:
• 107, a vlCDR2 having SEQ ID NO:
• 108, and a vlCDR3 having SEQ ID NO:
• 109, and wherein said second heavy variable domain and said second variable light domain bind PSMA.