Compounds for use as GPR120 agonists

A compound of formula (I):

• or a stereoisomer, a tautomer, a geometrical isomer, a pharmaceutically acceptable salt, a pharmaceutically acceptable solvate, a prodrug, an N-oxide, a S-oxide or a carboxylic acid isostere thereof;
• wherein:
• Ring A is a saturated or unsaturated optionally substituted 4- to 10-membered carbocycle;
• an optionally substituted 5- to 10-membered heteroaryl;
• or a saturated or partly saturated or unsaturated optionally substituted 5- to 10-membered heterocycle;
• wherein said heteroaryl or heterocycle contain 1, 2, 3 or 4 heteroatoms independently selected from N, O and S;
• Ring B and Ring C are independently selected from the group consisting of optionally substituted (C6-C10)aryl and optionally substituted 6- to 10-membered heteroaryl which contains 1, 2 or 3 heteroatoms independently selected from the group consisting of N, O and S;
• X is —(CR8R9)p—O—, (CR8R9)p—S—, —(CR8R9)p—N(R10)—, —O—(CR8R9)p—, —S—(CR8R9)p— or —N(R10)—(CR8R9)p;
• Y is —(CR14R15)g—;
• Q is —CO2M, —CONH2, —CONH[(C1-C6)alkyl], —CON[(C1-C6)alkyl]2 or —CONHSO2(C1-C6)alkyl;
• M is hydrogen, deuterium or (C1-C6)alkyl;
• R1 is
• wherein
• is point of attachment to Ring A;
• J is —CH2—, —CHF—, —CF2—, —CH[(C1-C6)alkyl]—, or —C[(C1-C6)alkyl]2-;
• “-----” represents an optional bond;
• Ra is hydrogen, (C1-C6)alkyl or halo(C1-C6)alkyl;
• R2 is selected from the group consisting of hydrogen, halogen, (C1-C6)alkyl, halo(C1-C6)alkyl, (C1-C6)alkoxy, hydroxy, (C3-C10)cycloalkyl, (C6-C10)aryl, heteroaryl, heterocyclyl, (C6-C10)aryl-(C1-C6)alkyl, (C1-C6)alkyl-(C6-C10)aryl-, (C6-C10)aryloxy, heterocyclyl-(C1-C6)alkyl, (C1-C6)alkyl-heterocyclyl, heteroaryl-(C1-C6)alkyl, (C1-C6)alkyl-heteroaryl, cyano, —NR10R11, —C(O)NR10R11, —C(S)NR10R11, —S(O)tR12 and —C(O)R13;
• or
• R1 and R2 are combined together with one or two atoms of Ring A to form:
• a 3- to 8-membered partly unsaturated or saturated carbocycle
• wherein the said carbocycle or heterocycle can be unsubstituted or substituted with the one or more groups independently selected from the group consisting of (C1-C6)alkenyl, (C1-C6)alkyl, halo(C1-C6)alkyl, (C1-C6)alkoxy, hydroxy, halogen, cyano, oxo, (C3-C10)cycloalkyl, (C6-C10)aryl, heteroaryl and heterocyclyl and
• wherein Ring A together with R1 and R2 does not form an unsubstituted tetrahydronaphthyl group;
• R3 at each occurrence, is independently selected from the group consisting of hydrogen, halogen, (C1-C6)alkyl, halo(C1-C6)alkyl, (C1-C6)alkoxy, hydroxy, (C3-C10)cycloalkyl, (C6-C10)aryl, heteroaryl, heterocyclyl, (C6-C10)aryl-(C1-C6)alkyl, (C1-C6)alkyl-(C6-C10)aryl, (C6-C10)aryloxy, heterocyclyl-(C1-C6)alkyl, (C1-C6)alkyl-heterocyclyl-, heteroaryl-(C1-C6)alkyl, (C1-C6)alkyl-heteroaryl, cyano, —NR10R11, —C(O)NR10R11, —C(S)NR10R11, —S(O)tR12 and —C(O)R13;
• R4 at each occurrence, is independently selected from the group consisting of hydrogen, (C1-C6)alkyl, halo(C1-C6)alkyl, (C1-C6)alkoxy, hydroxy, halogen, cyano, (C3-C10)cycloalkyl, (C6-C10)aryl, heteroaryl, heterocyclyl, (C6-C10)aryl-(C1-C6)alkyl, (C1-C6)alkyl-(C6-C10)aryl, (C6-C10)aryloxy, heterocyclyl-(C1-C6)alkyl, (C1-C6)alkyl-heterocyclyl, heteroaryl-(C1-C6)alkyl, (C1-C6)alkyl-heteroaryl, —NR10R11, —S(O)tR12 and —C(O)R13;
• R5 is selected from the group consisting of hydrogen, (C1-C6)alkyl, hydroxy, cyano, —COR10, —NR10R11, —CONR10R11, (C1-C6)alkylamino, di(C1-C6)alkylamino, (C1-C6)alkoxy, halo(C1-C6)alkyl, —S(O)tR12 and —C(O)R13;
• R6 and R7 are independently selected from the group consisting of hydrogen, (C1-C6)alkyl, halo(C1-C6)alkyl and halogen;
• R8 and R9 are independently selected from the group consisting of hydrogen, deuterium, (C1-C6)alkyl, halo(C1-C6)alkyl and halogen;
• or
• R8 and R9 together with the carbon atom they are attached to form:
• i) a 3- to 5-membered saturated carbocycle selected from the group consisting of cyclopropane, cyclobutane, cyclopentane and cyclohexane;
• or
• ii) a 4- to 6-membered saturated heterocycle selected from the group consisting of oxetane, thietane, azetidine, tetrahydrofuran, tetrahydrothiophene, pyrolidine and piperidine;
• R10 is hydrogen, hydroxy, (C1-C6)alkyl, halo(C1-C6)alkyl, (C1-C6)alkoxy, (C3-C10)cycloalkyl, (C6-C10)aryl, heterocyclyl, heteroaryl, (C6-C10)aryloxy, (C6-C10)aryl-(C1-C6)alkyl, (C1-C6)alkyl-(C6-C10)aryl, heterocyclyl-(C1-C6)alkyl, (C1-C6)alkyl-heterocyclyl, heteroaryl-(C1-C6)alkyl or (C1-C6)alkyl-heteroaryl or —S(O)tR12;
• R11 is hydrogen, hydroxy, (C1-C6)alkyl, halo(C1-C6)alkyl, (C3-C10)cycloalkyl, (C1-C6)alkoxy, (C3-C10)cycloalkyl, (C6-C10)aryl, heterocyclyl, heteroaryl, (C6-C10)aryloxy, (C6-C10)aryl-(C1-C6)alkyl, (C1-C6)alkyl-(C6-C10)aryl, heterocyclyl-(C1-C6)alkyl, (C1-C6)alkyl-heterocyclyl, heteroaryl-(C1-C6)alkyl, (C1-C6)alkyl-heteroaryl or —S(O)tR12;
• or
• R10 and R11 are combined together to form 3- to 8-membered saturated or unsaturated ring which contains 1, 2 or 3 heteroatoms independently selected from N, O and S;
• R12 and R13 are independently selected from the group consisting of hydrogen, (C1-C6)alkyl, halo(C1-C6)alkyl, (C3-C10)cycloalkyl, (C6-C10)aryl, heterocyclyl, heteroaryl, (C6-C10)aryl-(C1-C6)alkyl, (C1-C6)alkyl-(C6-C10)aryl, heterocyclyl-(C1-C6)alkyl, (C1-C6)alkyl-heterocyclyl, heteroaryl-(C1-C6)alkyl and (C1-C6)alkyl-heteroaryl;
• R14 and R15 are independently selected from the group consisting of hydrogen, (C1-C6)alkyl, halo(C1-C6)alkyl and halogen;
• or
• R14 and R15 are combined together to form a 3- to 5-membered saturated carbocycle or 4- to 6-membered saturated heterocycle which optionally contains 1 or 2 heteroatoms independently selected from the group consisting of N, O and S;
• wherein the said carbocycle or heterocycle can be unsubstituted or substituted;
• g is 2, 3, 4, 5 or 6;
• m is 0, 1 or 2;
• n is 0, 1 or 2;
• p is 1, 2 or 3;
• r is 0, 1, 2, 3 or 4;
• t is 0, 1 or 2;
• wherein
• (C1-C6)alkyl is unsubstituted or substituted with one or more groups independently selected from the group consisting of (C1-C6)alkyl, halogen, halo(C1-C6)alkyl, hydroxy, (C1-C6)alkoxy, halo(C1-C6)alkoxy, (C3-C10)cycloalkyl, (C6-C10)aryl, (C6-C10)aryloxy, heterocyclyl, heteroaryl, amino, cyano, nitro, —NH(C1-C6)alkyl, —N[(C1-C6)alkyl]2, —C(O)(C1-C6)alkyl, —C(O)O(C1-C6)alkyl, —C(O)NH2, —C(O)NH(C1-C6)alkyl, —C(O)N[(C1-C6)alkyl]2 and —C(O)NHSO2(C1-C6)alkyl;
• (C3-C10)cycloalkyl is unsubstituted or substituted with one or more groups independently selected from the group consisting of (C1-C6)alkyl, halogen, halo(C1-C6)alkyl, hydroxy, (C1-C6)alkoxy, halo(C1-C6)alkoxy, amino, cyano and nitro;
• carbocycle is unsubstituted or substituted with one or more groups independently selected from the group consisting of (C1-C6)alkyl, halo(C1-C6)alkyl, hydroxy, halogen, (C1-C6)alkoxy, halo(C1-C6)alkoxy, (C6-C10)aryl, (C3-C10)cycloalkyl, heteroaryl, heterocyclyl, amino, cyano, nitro, —C(O)O(C1-C6)alkyl, —C(O)NR10R11 and —S(O)tR12;
• wherein R10, R11, R12 and t are as defined above;
• (C6-C10)aryl is unsubstituted or substituted with one or more groups independently selected from the group consisting of (C1-C6)alkyl, halogen, halo(C1-C6)alkyl, hydroxy, (C1-C6)alkoxy, halo(C1-C6)alkoxy, (C3-C10)cycloalkyl, (C6-C10)aryl, heterocyclyl, heteroaryl, amino, cyano, nitro, —C(O)O(C1-C6)alkyl, —C(O)NR10R11 and —S(O)tR12;
• wherein R10, R11, R12 and t are as defined above;
• heterocyclyl is unsubstituted or substituted with one or more groups independently selected from the group consisting of (C1-C6)alkyl, halogen, halo(C1-C6)alkyl, hydroxy, (C1-C6)alkoxy, halo(C1-C6)alkoxy, (C3-C10)cycloalkyl, (C6-C10)aryl, heterocyclyl, heteroaryl, amino, cyano, nitro, —C(O)NR10R11 and —S(O)tR12;
• wherein R10, R11, R12 and t are as defined above;
• heteroaryl is unsubstituted or substituted with one or more groups independently selected from the group consisting of (C1-C6)alkyl, halogen, halo(C1-C6)alkyl, hydroxy, (C1-C6)alkoxy, halo(C1-C6)alkoxy, heterocyclyl, heteroaryl, amino, cyano, nitro, —C(O)NR10R11 and —S(O)tR12;
• wherein R10, R11, R12 and t are as defined above.