3-amino-1,5,6,7-tetrahydro-4H-indol-4-ones

A compound of formula (I),

• wherein:
• R1 is hydrogen or C1-C6-alkyl;
• R2 is hydroxy, C2-C4-alkenyl, R7R8N—, R10—O—C(O)—, R7R8N—C(O)—, R6—C(O)—NR9—, or R11—(C1-C4-alkyl)-,
• wherein said C2-C4-alkenyl is optionally substituted with halogen, R10—O—C(O)—, R7R8N- or phenyl, wherein said phenyl group is optionally substituted, one or more times with R4;
• R3 is hydrogen or C1-C6-alkyl;
• A is a group selected from:
• wherein * indicates the point of attachment of said group with the rest of the molecule and said group is optionally substituted, one or more times with R4;
• each R4 is independently halogen, hydroxy, nitro, cyano, C1-C4-alkyl, C1-C4-alkoxy, C1-C4-haloalkyl, C1-C4-haloalkoxy, C1-C4-hydroxyalkyl, C1-C4-alkyl-C(O)—, R10—O—C(O)—, R7R8N—C(O)—, C1-C4-alkyl-C(O)—NH—, R7R8N—, or R7R8N—SO2—;
• E is a group
• wherein * indicates the point of attachment of said group with the rest of the molecule;
• each R5 is independently halogen, hydroxy, nitro, cyano, R9R10N—, (R13—C(O)—)(R14—C(O)—)N—, C1-C4-alkyl, C3-C6-cycloalkyl, C1-C6-alkoxy, C1-C4-haloalkyl, C1-C6-haloalkoxy, R6—C(O)—NR9— or R7R8N—C(O)—NR9—,
• wherein said C1-C4-alkoxy is optionally substituted, one or more times, independently from each other, with a substituent selected from hydroxy, C1-C4-alkoxy, C3-C6-cycloalkyl, and 4- to 6-membered heterocycloalkyl;
• Q is O or N—OH;
• each R6 is independently C1-C6-alkyl, C3-C6-cycloalkyl, 4- to 6-membered heterocycloalkyl, phenyl or heteroaryl,
• wherein said C1-C6-alkyl is optionally substituted, one or more times, independently from each other, with halogen, hydroxy, nitro, cyano, C1-C4-alkoxy, C1-C4-haloalkoxy, C3-C6-cycloalkyl, R7R8N- or phenyl optionally substituted, one or more times with R4,
• wherein said C3-C6-cycloalkyl, 4- to 6-membered heterocycloalkyl, phenyl or heteroaryl groups are optionally substituted, one or more times, independently from each other, with halogen, hydroxy, nitro, cyano, C1-C6-alkyl, C1-C4-alkoxy, C1-C4-haloalkyl, R10—O—C(O)— or C1-C4-haloalkoxy;
• R7 and R8 are independently hydrogen, C1-C6-alkyl, C3-C6-cycloalkyl, R10—O—C(O)— or phenyl,
• wherein said C1-C6-alkyl is optionally substituted, one or more times, independently from each other, with halogen, hydroxy, C1-C4-alkoxy, C1-C4-haloalkoxy, C3-C6-cycloalkyl optionally substituted one time with hydroxy, 4- to 6-membered heterocycloalkyl, heteroaryl, or R9R10N—,
• wherein said phenyl group is optionally substituted, one or more times with R4;
• or,
• R7 and R8 together with the nitrogen atom to which they are attached form a 4- to 7-membered nitrogen containing heterocyclic ring, optionally containing one additional heteroatom selected from O, NR9 and S, and which may be optionally substituted, one or more times with R12;
• wherein two R12 substituents attached to the same ring carbon atom are optionally taken together with the carbon atom to which they are attached to form a cyclobutane, azetidine, or oxetane group;
• said azetidine being optionally substituted one time with C1-C3-alkyl;
• or,
• R7 and R8 together with the nitrogen atom to which they are attached form a group selected from:
• wherein * indicates the point of attachment of said group with the rest of the molecule;
• R9 is hydrogen or C1-C6-alkyl;
• R10 is hydrogen, C1-C6-alkyl or C3-C6-cycloalkyl;
• R11 is hydroxy, nitro, cyano, C3-C6-cycloalkyl, 4- to 6-membered heterocycloalkyl, C1-C4-alkyl-C(O)—, R10—O—C(O)—, R7R8N—C(O)—, C1-C4-alkoxy, C1-C4-haloalkoxy, R7R8N—, N3—, R6—C(O)—NR9—, R6—O—C(O)—NR9—, R7R8N—C(O)—NR9—, R6—SO2—NR9—, R6—S—, R6—SO—, R6—SO2—, or R7R8N—SO2—,
• wherein said C3-C6-cycloalkyl or 4- to 6-membered heterocycloalkyl groups are optionally substituted, one or more times, independently from each other, with halogen, hydroxy, cyano, C1-C4-alkyl, C1-C4-alkoxy, C1-C4-haloalkyl or C1-C4-haloalkoxy,
• wherein said C1-C4-alkoxy is optionally substituted with phenyl,
• wherein said phenyl group is optionally substituted, one or more times with R4;
• each R12 is independently halogen, hydroxy, C1-C4-alkyl, C1-C4-alkoxy, C1-C4-haloalkyl, C1-C4-haloalkoxy, or R9R10N—;
• R13 and R14 are independently C1-C4-alkyl, or C3-C6-cycloalkyl,
• wherein said C3-C6-cycloalkyl is optionally substituted, one or more times, independently from each other, with halogen;
• and
• m is 0, 1 or 2;
• or an N-oxide, a salt, a tautomer or a stereoisomer of said compound, or a salt of said N-oxide, tautomer or stereoisomer.