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US 10,214,761 B2Granted
Amino acid derivatives
AssigneeMedImmune, LLC
InventorsKenneth H. Grabstein, Michael Van Brunt, Marcello Marelli
Life of this patent
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Abstract
There are provided amino acid derivatives of formula V and VI as defined herein which are pyrrolysine analogs for use in bioconjugation processes.
Claims16
A pyrrolysine analog selected from the group consisting of:
- (a) a pyrrolysine analog of Formula VI:
- wherein
- Z=CH2, CH—NH2, CH—OH, O, S;
- FG =azide, alkene, alkyne, ketone, ester, aryl or cycloalkyne;
- and
- b=an integer 1-4;
- and
- (b) pyrrolysine analog of Formula V:
- wherein
- Z=bond, CH—OH, NH, or S;
- b is 0 or an integer 1-7;
- and
- FG=alkene, alkyne, aromatic ketone, ester, aryl or cycloalkyne.
10 more elements
Dependencies are inferred from the claim text.