Polyglyoxylates, manufacture and use thereof
AssigneeThe University of Western Ontario
InventorsElizabeth R. Gillies, Bo Fan, Andrew D. Wong, John F. Trant
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Abstract
Self-immolative polymers degrade by an end-to-end depolymerization mechanism in response to the cleavage of a stabilizing end-cap from the polymer terminus. Examples include homopolymers, mixed polymers including block copolymers, suitable for a variety of applications. A polyglyoxylate can be end-capped or capped with a linker as in a block copolymer.
Claims18
A capped polymer comprising a polyglyoxylate polymer having a polyacetal backbone with pendant esters and a terminal hydroxyl, an end capping molecule separate from the polymer that is a protecting group for the polyglyoxylate's terminal hydroxyl or a self-immolative spacer covalently linked to the protecting group, which is linked to an end thereof by a covalent linkage, wherein the end capping molecule is able to undergo selective cleavage from the polyglyoxylate polymer upon exposure to a preselected stimulus, wherein said selective cleavage is cleavage only of said covalent linkage of the end capping molecule to the end of the polymer thus leaving the polyacetal backbone and the pendant esters intact to produce the polyglyoxylate polymer without the end capping molecule.
Dependencies are inferred from the claim text.