Antimicrobial peptides derived from hepatitis B virus core protein arginine-rich domain
AssigneeAcademia Sinica
InventorsChiaho Shih, Heng-Li Chen, Pei-Yi Su
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Abstract
A pharmaceutical composition for use in killing and/or inhibiting the growth and/or proliferation of a microorganism in a subject in need thereof, or for treating a subject afflicted with a microbial infection is disclosed. The composition comprises: (a) an effective amount of an isolated peptide, wherein the peptide comprises the arginine-rich carboxy-terminal region of hepatitis B virus core protein (HBc) and exhibits an antimicrobial activity; and (b) a pharmaceutically acceptable carrier. The peptide exhibits an activity against Gram-negative bacteria, Gram-positive bacteria, and/or fungi.
Claims7
A pharmaceutical composition comprising:
- (a) an effective amount of an isolated peptide, wherein the peptide consists of a protecting group and the amino acid sequence of SEQ ID NO:1, and exhibits an anti-bacterial or anti-fungal activity;
- and
- (b) a pharmaceutically acceptable carrier.
A method of killing or inhibiting proliferation of a microorganism or treating a microbial infection in a subject, comprising:
- administering to a subject in need thereof a pharmaceutical composition that contains (a) an effective amount of an isolated peptide and (b) a pharmaceutically acceptable carrier, the microorganism being a bacterium or fungus and the microbial infection being a bacterial or fungal infection, wherein the peptide comprises the amino acid sequence of SEQ ID NO:
- 1.
Dependencies are inferred from the claim text.