Modified macrocyclic compounds

A compound of formula (I)

• wherein:
• A is a bivalent moiety selected from the group consisting of —S—, —S(═O)—, —S(═O)2—, and —S(═O)(═NR5)—;
• G and E are independently a bivalent moiety selected from the group consisting of —O—, —N(RA)—, —CH2—, —CH(C1-C6-alkyl)-, —C(C1-C6-alkyl)2-, —S—, —S(═O)—, and —S(═O)2—,
• with the proviso that at least one of said bivalent moieties G and E is different from —O—;
• L is a C2-C8-alkylene moiety,
• wherein said moiety is optionally substituted with
• (i) one substituent selected from the group consisting of hydroxy, —NR6R7, C2-C3-alkenyl-, C2-C3-alkynyl-, C3-C4-cycloalkyl-, hydroxy-C1-C3-alkyl, and —(CH2)NR6R7, and/or
• (ii) one or two or three or four substituents independently selected from the group consisting of halogen and C1-C3-alkyl-,
• or wherein
• one carbon atom of said C2-C8-alkylene moiety forms a three- or four-membered ring together with a bivalent moiety to which it is attached, wherein said bivalent moiety is selected from the group consisting of —CH2CH2—, —CH2CH2CH2—, and —CH2OCH2—;
• X and Y are CH or N, with the proviso that one of X and Y is CH and one of X and Y is N;
• R1 is a group selected from the group consisting of C1-C6-alkyl-, C3-C6-alkenyl-, C3-C6-alkynyl-, C3-C7-cycloalkyl-, heterocyclyl-, phenyl-, heteroaryl-, phenyl-C1-C3-alkyl- and heteroaryl-C1-C3-alkyl-,
• wherein said group is optionally substituted with one or two or three substituents independently selected from the group consisting of hydroxy, cyano, halogen, C1-C6-alkyl-, halo-C1-C3-alkyl-, C1-C6-alkoxy-, C1-C3-fluoroalkoxy-, —NH2, alkylamino-, dialkylamino-, acetylamino-, N-methyl-N-acetylamino-, cyclic amines, —OP(═O)(OH)2, —C(═O)OH, and —C(═O)NH2;
• R2 is a group selected from the group consisting of a hydrogen atom, a fluorine atom, a chlorine atom, a bromine atom, cyano, C1-C3-alkyl-, C1-C3-alkoxy-, halo-C1-C3-alkyl-, and C1-C3-fluoroalkoxy-;
• R3 and R4 are independently a group selected from the group consisting of a hydrogen atom, a fluorine atom, a chlorine atom, a bromine atom, cyano, C1-C3-alkyl-, C1-C3-alkoxy-, halo-C1-C3-alkyl-, and C1-C3-fluoroalkoxy-;
• R5 is a group selected from the group consisting of a hydrogen atom, cyano, —C(═O)R8, —C(═O)OR8, —S(═O)2R8, —C(═O)NR6R7, C1-C6-alkyl-, C3-C7-cycloalkyl-, heterocyclyl-, phenyl-, and heteroaryl-,
• wherein said C1-C6-alkyl-, C3-C7-cycloalkyl-, heterocyclyl-, phenyl- or heteroaryl-group is optionally substituted with one, two or three substituents independently selected from the group consisting of halogen, hydroxy, cyano, C1-C3-alkyl-, C1-C3-alkoxy-, —NH2, alkylamino-, dialkylamino-, acetylamino-, N-methyl-N-acetylamino-, cyclic amines, halo-C1-C3-alkyl-, and C1-C3-fluoroalkoxy-;
• R6 and R7 are independently a group selected from the group consisting of a hydrogen atom, C1-C6-alkyl-, C3-C7-cycloalkyl-, heterocyclyl-, phenyl-, benzyl- and heteroaryl-,
• wherein said C1-C6-alkyl-, C3-C7-cycloalkyl-, heterocyclyl-, phenyl-, benzyl- or heteroaryl-group is optionally substituted with one, two or three substituents independently selected from the group consisting of halogen, hydroxy, C1-C3-alkyl-, C1-C3-alkoxy-, —NH2, alkylamino-, dialkylamino-, acetylamino-, N-methyl-N-acetylamino-, cyclic amines, halo-C1-C3-alkyl-, and C1-C3-fluoroalkoxy-,
• or
• R6 and R7 are taken together with the nitrogen atom to which they are attached to form a cyclic amine;
• R8 is a group selected from the group consisting of C1-C6-alkyl-, halo-C1-C3-alkyl-, C3-C7-cycloalkyl-, heterocyclyl-, phenyl-, benzyl- and heteroaryl-,
• wherein said group is optionally substituted with one, two or three substituents independently selected from the group consisting of halogen, hydroxy, C1-C3-alkyl-, C1-C3-alkoxy-, —NH2, alkylamino-, dialkylamino-, acetylamino-, N-methyl-N-acetylamino-, cyclic amines, halo-C1-C3-alkyl-, and C1-C3-fluoroalkoxy-;
• and
• RA is a hydrogen atom or a C1-C6-alkyl-group,
• or an enantiomer, a diastereomer, a salt, or a solvate thereof, or a salt of said solvate.