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US 10,213,483 B2Granted
Oligopeptidic compounds and uses thereof
AssigneeApim Therapeutics AS
InventorsMarit Otterlei, Per Arne Aas, Emadoldin Feyzi
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AssigneeApim Therapeutics AS
InventorsMarit Otterlei, Per Arne Aas, Emadoldin Feyzi
Estimating the term…
Disclosed is A method of treatment of a disorder or condition where it is desirable to inhibit the growth of cells, or a method of treatment which involves cytostatic therapy by administering an oligopeptidic compound to a subject in need thereof. The oligopeptidic compound is capable of interacting with proliferating cell nuclear antigen (PCNA) The compound comprises a PCNA interacting motif which is: which is: [K/R]-[F/Y/W]-[L/I/V/A/M]-[L/I/V/A/M]-[K/R] (SEQ ID NO. 28). The oligopeptidic compound has 9-70 subunits and at least one signal sequence. The signal sequence is a nuclear localization signal sequence and/or a cell penetrating signal sequence. In the compound a PCNA interacting motif is N-terminal to a signal sequence.
A method of treatment of a hyperproliferative disorder, said method comprising administering an oligopeptidic compound to a subject in need thereof, wherein said oligopeptidic compound interacts with proliferating cell nuclear antigen (PCNA), wherein the compound comprises a PCNA interacting motif which is:
A method of treatment of a hyperproliferative disorder comprising:
Dependencies are inferred from the claim text.